DOC2A and EIF3C

		DOC2A	EIF3C
Description		double C2 domain alpha	eukaryotic translation initiation factor 3 subunit C
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GO Annotations	Cellular Component	Lysosome Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Translation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 25056061 28991256 29483656)	Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)
Interacting Genes		6 interacting genes: DYNLT1 FOXP1 RAP1GDS1 STXBP1 UBASH3B UNC13B	23 interacting genes: AAGAB ALKBH4 BTG3 CALM1 COXFA4L2 DSCAM EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 PFDN1 PLEKHF2 RNF10 RPS6KA3 SMAD9 SNCA SNIP1 TACC3 TRAPPC2
Entrez ID		8448	8663
HPRD ID		05195	04889
Ensembl ID		ENSG00000149927	ENSG00000184110
Uniprot IDs		Q14183	Q99613
PDB IDs		4MJJ	3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Syntaxin-1 Binding Synaptic Vesicle Priming Negative Regulation Of Cell Differentiation Secretory Granule Localization Nuclear Androgen Receptor Binding Calcium-ion Regulated Exocytosis Negative Regulation Of Developmental Process Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling CAAX-box Protein Maturation Platelet Aggregation Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Negative Regulation Of Cell Development Vesicle Docking Homotypic Cell-cell Adhesion Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Organelle Localization By Membrane Tethering Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Positive Regulation Of Interleukin-21 Production Membrane Docking Regulation Of Signal Transduction Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Cell Development Negative Regulation Of Neuron Maturation Basal Dendrite Morphogenesis Basal Dendrite Arborization Regulated Exocytosis Establishment Of Vesicle Localization Myosin Filament Assembly Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Differentiation [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Regulation Of Transport Platelet Degranulation Vesicle Localization Regulation Of Glutamate Secretion, Neurotransmission	Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Translation Initiation Factor Activity Translational Initiation Cytoplasmic Translational Initiation Protein-RNA Complex Assembly Regulation Of Acyl-CoA Biosynthetic Process Translation Vesicle-mediated Transport In Synapse Positive Regulation Of Vesicle Fusion
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