CD40 and RPS5

		CD40	RPS5
Description		CD40 molecule	ribosomal protein S5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding
	Biological Process	Immune System Process Regulation Of Immunoglobulin Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Calcium Ion Homeostasis Defense Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Bacterium Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Response To Nutrient Levels Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Type II Interferon Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Defense Response To Protozoan Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process	Cytoplasmic Translation Translation Translational Initiation Regulation Of Translational Fidelity Ribosomal Small Subunit Biogenesis
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Lucatumumab Dacetuzumab	Artenimol
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233 28067908) Kawasaki disease ( 33106546 22446961 22446962) Multiple sclerosis ( 19525955 24076602 22190364 21833088) Rheumatoid arthritis ( 24390342 23143596 30423114 18794853) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC61A1 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	4 interacting genes: FILNC1 MDM2 MYCBP2 PTEN
Entrez ID		958	6193
HPRD ID		00178	04695
Ensembl ID		ENSG00000101017	ENSG00000083845
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 A0A8Q3SI60 P25942 Q6P2H9	P46782
PDB IDs		1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9 7P3I 8YX1 8YX9	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway CD40 Receptor Complex Tumor Necrosis Factor Receptor Binding Thioesterase Binding Interleukin-17-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Cell Surface Receptor Signaling Pathway Response To Stress Regulation Of Immune Response Regulation Of Innate Immune Response Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Response To Other Organism Positive Regulation Of Post-translational Protein Modification Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Defense Response Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Immune System Process Immune Response Positive Regulation Of Lymphocyte Activation Regulation Of Apoptotic Process Toll-like Receptor 4 Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ubiquitin Protein Ligase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Protein-containing Complex Protein Binding CD40 Receptor Binding Defense Response To Other Organism Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Activation Immune System Process Regulation Of Programmed Cell Death Response To External Biotic Stimulus Innate Immune Response Positive Regulation Of Protein Ubiquitination Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of DNA-binding Transcription Factor Activity	Enzyme Binding Regulation Of Locomotion Response To Vitamin Regulation Of Developmental Process Regulation Of Protein Stability Regulation Of Cell Projection Organization Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Neuron Projection Development Negative Regulation Of Synaptic Vesicle Clustering Central Nervous System Neuron Axonogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin Beta-catenin Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Vitamin B1 Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Water-immersion Restraint Stress Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Actinomycin D Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Response To Nutrient Regulation Of Smooth Muscle Cell Proliferation Regulation Of Protein Kinase C Signaling Positive Regulation Of Metabolic Process Response To Erythropoietin Intracellular Signal Transduction Cellular Response To Erythropoietin NEDD8 Ligase Activity Response To Actinomycin D Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-dependent Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To UV-C Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Cell Projection Organization Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
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