AKT1S1 and RICTOR

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		AKT1S1	RICTOR
Gene Name		AKT1 substrate 1 (proline-rich)	RPTOR independent companion of MTOR, complex 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Cytosol TORC2 Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Ribosome Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Cellular Response To Heat	Positive Regulation Of Endothelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Peptidyl-serine Phosphorylation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Actin Cytoskeleton Reorganization TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) HSF1-dependent transactivation PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: AKT1 AKT2 EIF6 MAPKAP1 MLST8 MTOR RICTOR RPS6KA5 RPTOR TCEA2 YWHAG YWHAQ	13 interactors: AKT1 AKT1S1 CHUK CUL1 EIF4EBP1 GSK3B HDAC1 IKBKB ILK MTOR RPS6KB1 SGK1 SIRT1
Entrez ID		84335	253260
HPRD ID		12441	10682
Ensembl ID		ENSG00000204673	ENSG00000164327
Uniprot IDs		Q96B36	Q6R327
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorylation Response To Peptide Hormone Positive Regulation Of T Cell Activation Cellular Response To Organonitrogen Compound Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Response To Peptide Regulation Of Fatty Acid Beta-oxidation Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Rac GTPase Activity TOR Signaling Fc Receptor Signaling Pathway Positive Regulation Of TOR Signaling Cellular Response To Hormone Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Heat	Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Response To Heat Intracellular Signal Transduction Phosphatidylinositol-mediated Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Temperature Stimulus Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Response To Heat Cellular Response To Organic Substance Peptidyl-serine Phosphorylation Fc Receptor Signaling Pathway Regulation Of Cell Size Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Cell Size Response To Organic Substance Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Immune Response Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death TOR Signaling Regulation Of Cell Cycle Regulation Of Cell Proliferation
Tagcloud ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk
Tagcloud (Difference) ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rps6kb1 s6 s6k1 senescent ureahydrolase wk
Tagcloud (Intersection) ?