AKT1S1 and MAPKAP1

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		AKT1S1	MAPKAP1
Gene Name		AKT1 substrate 1 (proline-rich)	mitogen-activated protein kinase associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Ras GTPase Binding Protein Kinase Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Cellular Response To Heat	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Substantia Nigra Development T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) HSF1-dependent transactivation PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AKT1 AKT2 EIF6 MAPKAP1 MLST8 MTOR RICTOR RPS6KA5 RPTOR TCEA2 YWHAG YWHAQ	8 interactors: ABCB1 AKT1S1 CDC42EP1 ECI1 EIF4EBP1 MAPK8 PRR5L YWHAG
Entrez ID		84335	79109
HPRD ID		12441	17464
Ensembl ID		ENSG00000204673	ENSG00000119487
Uniprot IDs		Q96B36	Q9BPZ7
PDB IDs			3VOQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorylation Response To Peptide Hormone Positive Regulation Of T Cell Activation Cellular Response To Organonitrogen Compound Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Response To Peptide Regulation Of Fatty Acid Beta-oxidation Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Rac GTPase Activity TOR Signaling Fc Receptor Signaling Pathway Positive Regulation Of TOR Signaling Cellular Response To Hormone Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Heat	Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Organization TORC2 Signaling G2/M Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Regulation Of Signaling Mitotic Cell Cycle IRES-dependent Translational Initiation Cap-independent Translational Initiation JUN Phosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Xenobiotic Transport Positive Regulation Of Deacetylase Activity Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Signaling Negative Regulation Of Cellular Metabolic Process Response To Stimulus Cytoplasmic Translational Initiation Fc Receptor Signaling Pathway Cell Communication Cell Cycle Process
Tagcloud ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed
Tagcloud (Difference) ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed
Tagcloud (Intersection) ?