AKT1S1 and MLST8

Number of citations of the paper that reports this interaction (PMID 18030348)
59

Data Source:
BioGRID (enzymatic study)

		AKT1S1	MLST8
Gene Name		AKT1 substrate 1 (proline-rich)	MTOR associated protein, LST8 homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Cellular Response To Heat	Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Response To Heat
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) HSF1-dependent transactivation PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease mTOR signalling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling S6K1-mediated signalling mTORC1-mediated signalling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling S6K1-mediated signalling mTORC1-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway HSF1-dependent transactivation IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Release of eIF4E VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Release of eIF4E Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: AKT1 AKT2 EIF6 MAPKAP1 MLST8 MTOR RICTOR RPS6KA5 RPTOR TCEA2 YWHAG YWHAQ	9 interactors: A2M AKT1S1 ATXN1 EIF4EBP1 MTOR PRMT1 PRR5L RPS6KB1 RPTOR
Entrez ID		84335	64223
HPRD ID		12441	17031
Ensembl ID		ENSG00000204673	ENSG00000167965
Uniprot IDs		Q96B36	Q9BVC4
PDB IDs			4JSN 4JSP 4JSV 4JSX 4JT5 4JT6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorylation Response To Peptide Hormone Positive Regulation Of T Cell Activation Cellular Response To Organonitrogen Compound Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Response To Peptide Regulation Of Fatty Acid Beta-oxidation Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Rac GTPase Activity TOR Signaling Fc Receptor Signaling Pathway Positive Regulation Of TOR Signaling Cellular Response To Hormone Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Heat	TOR Signaling Response To Heat Regulation Of Cellular Response To Heat Insulin Receptor Signaling Pathway Response To Temperature Stimulus Intracellular Signal Transduction Cellular Response To Insulin Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Heat Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Response To Insulin Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Transcription From RNA Polymerase III Promoter Enzyme Linked Receptor Protein Signaling Pathway Response To Amino Acid Regulation Of Signal Transduction Negative Regulation Of Cell Size Regulation Of Cell Size Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorylation Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Translation Negative Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cellular Component Size Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Stimulus Response To Hormone Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Translation
Tagcloud ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 mtor mtorc1 mtorc2 multiprotein pras40 protor raptor representing rictor s6k1 ser473 stream suppresses threonine tsc2
Tagcloud (Difference) ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 mtor mtorc1 mtorc2 multiprotein pras40 protor raptor representing rictor s6k1 ser473 stream suppresses threonine tsc2
Tagcloud (Intersection) ?