THOC3 and DDX39B

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology)

		THOC3	DDX39B
Name		THO complex subunit 3	DExD-box helicase 39B
Structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Speck	Transcription Export Complex Nucleus Nucleoplasm Spliceosomal Complex U4 SnRNP U6 SnRNP Cytoplasm Nuclear Speck
	Molecular Function	RNA Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity U6 SnRNA Binding U4 SnRNA Binding Identical Protein Binding ATP-dependent Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle
Drugs		None	Artenimol
GWAS		Chronotype ( 30696823 )	Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) High light scatter reticulocyte count ( 32888494 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Mean platelet volume ( 27863252 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 27863252 ) Mosquito bite size ( 28199695 ) Myositis ( 26291516 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Ulcerative colitis ( 28067908 )
Interacting Genes		7 interacting genes: BRCA1 DDX39B DLG4 MLKL PFKFB4 PTEN TK1	31 interacting genes: ALYREF BARD1 DDX39A DNM2 EXOSC9 FANCA HIPK2 HNRNPLL IL7R LUZP4 NCBP2 OGT PIAS2 PKM RBM39 RNF4 RPS15A SARNP SDCBP SNRPA SREBF1 SREK1 SRPK2 STRN4 TDG THOC3 THOC6 TUBB3 UBE2I YWHAG ZHX1
Entrez ID		84321	7919
HPRD ID		09497	00805
Ensembl ID		ENSG00000051596	ENSG00000198563
Uniprot IDs		Q96J01	A0A024RCM3 Q13838
PDB IDs		7APK 7ZNK 7ZNL	1T5I 1T6N 1XTI 1XTJ 1XTK 7APK 7ZNK 7ZNL 8ENK
GO Terms Enriched among Interactors		Dendritic Spine Morphogenesis Identical Protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization P2Y1 Nucleotide Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein-containing Complex Assembly PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Thymidine Kinase Activity Cellular Component Assembly Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior ATP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission DNA Synthesis Involved In Mitotic DNA Replication Execution Phase Of Necroptosis Protein-containing Complex Organization BRCA1-B Complex Cellular Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Phase Transition AMPA Glutamate Receptor Clustering Dendritic Spine Neuroligin Family Protein Binding Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process Negative Regulation Of Centriole Replication Negative Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex	RNA Binding Nucleoplasm MRNA Metabolic Process Nucleus Nuclear Speck Nuclear Export MRNA Export From Nucleus MRNA Transport MRNA Processing Transcription Export Complex RNA Export From Nucleus RNA Transport RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Transport Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport RNA Metabolic Process PML Body Nucleic Acid Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein K6-linked Ubiquitination Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II THO Complex Part Of Transcription Export Complex U1 SnRNP Binding MRNA Binding Regulation Of MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Macromolecule Metabolic Process Response To Insulin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process