THOC3 and MLKL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		THOC3	MLKL
Gene Name		THO complex 3	mixed lineage kinase domain-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Nucleoplasm Golgi Apparatus Nuclear Speck Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane
	Molecular Function	RNA Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Complex Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing Viral MRNA Export From Host Cell Nucleus	Protein Phosphorylation Protein Homotrimerization Necroptotic Process
Pathways
Drugs
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		4 interactors: BRCA1 DDX39B MLKL TK1	5 interactors: ANAPC11 CDK1 NDUFB7 RAD18 THOC3
Entrez ID		84321	197259
HPRD ID		09497	08752
Ensembl ID		ENSG00000051596	ENSG00000168404
Uniprot IDs		Q96J01	Q8NB16
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H4-K20 Methylation Fetal Process Involved In Parturition Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Response To DNA Damage Stimulus Skeletal Muscle Cell Proliferation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation RNA Secondary Structure Unwinding Negative Regulation Of DNA Damage Checkpoint Protein Homooligomerization Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Response To Cortisol Thymidine Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Viral MRNA Export From Host Cell Nucleus Deoxyribonucleoside Monophosphate Biosynthetic Process Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Centriole Replication Regulation Of DNA Damage Checkpoint Positive Regulation Of Histone H3-K4 Methylation Protein Oligomerization Cellular Component Assembly Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction Resulting In Transcription Response To Steroid Hormone Regulation Of Cell Cycle Process Negative Regulation Of Histone Methylation Negative Regulation Of Centrosome Duplication Regulation Of DNA Methylation Negative Regulation Of Histone Acetylation Positive Regulation Of Histone Acetylation Parturition Protein Homotrimerization Negative Regulation Of Peptidyl-lysine Acetylation Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Postreplication Repair Positive Regulation Of Protein Acetylation	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Pronuclear Fusion Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Schwann Cell Differentiation Positive Regulation Of Proteolysis Viral MRNA Export From Host Cell Nucleus Mitotic Nuclear Division Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of DNA Recombination Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Protein K11-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Protein Ubiquitination Intracellular Transport Of Virus Nucleobase-containing Compound Metabolic Process DNA Repair Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Protein Modification By Small Protein Conjugation Positive Regulation Of Cardiac Muscle Cell Proliferation
Tagcloud ?			allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk1 ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Difference) ?			allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk1 ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Intersection) ?