THOC3 and DLG4

Number of citations: 54 (PubMedID 21653829)
Data Source: BioGRID (two hybrid)

		THOC3	DLG4
Name		THO complex subunit 3	discs large MAGUK scaffold protein 4
Structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Speck	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Voltage-gated Potassium Channel Complex Postsynaptic Density Membrane Cell Junction Axon Dendrite Endocytic Vesicle Membrane Cortical Cytoskeleton Neuromuscular Junction AMPA Glutamate Receptor Complex Dendrite Cytoplasm Cell Projection Neuron Projection Dendritic Spine Organelle Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Cell Periphery Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	RNA Binding	Protein Binding Kinase Binding Protein Kinase Binding Protein Phosphatase Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Neuroligin Family Protein Binding Scaffold Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport	Negative Regulation Of Receptor Internalization Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Cellular Response To Potassium Ion Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Protein-containing Complex Assembly Vocalization Behavior AMPA Glutamate Receptor Clustering Receptor Localization To Synapse Cell-cell Adhesion NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Grooming Behavior
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Signaling by ERBB4 Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		None	Guanidine Guanosine-5'-Monophosphate
GWAS		Chronotype ( 30696823 )	Cholesterol, total ( 24097068 25961943 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) LDL cholesterol ( 24097068 25961943 ) LDL cholesterol levels ( 28334899 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514 ) Serum alkaline phosphatase levels ( 29403010 33547301 )
Interacting Genes		7 interacting genes: BRCA1 DDX39B DLG4 MLKL PFKFB4 PTEN TK1	139 interacting genes: ABHD17A ACTN2 ADGRB1 ADGRB2 ADGRL1 ADRB1 AKAP5 ARHGAP32 ARRB2 ASIC3 ATP2B2 ATP2B4 BEGAIN CACNG2 CASK CD46 CIT CLU CNKSR2 CRHR1 CRIPT CYLD DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DRD1 DSCAM DYNLL1 EEF1G EFNB2 ERBB2 ERBB4 ERBIN EXOC4 FTH1 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GOLGA2 GPSM2 GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HNRNPC HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN LZTS2 MAP1A MAP3K10 MAPK12 MDM2 MPND MPP1 MT-CO1 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOMO1 NOS1 PCDH10 PCMT1 PEX19 PICK1 PRKCA PRR16 PTK2B PTPRG RALBP1 RASSF4 RPS6KA1 SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SLC4A7 SPRR2A SRC SYNGAP1 TAMALIN TANC1 THOC3 TIAM1 TJAP1 TRAF6 TUBB2B UBE3A VANGL2 VMAC WDR74 WNT3A YES1 ZDHHC17
Entrez ID		84321	1742
HPRD ID		09497	04199
Ensembl ID		ENSG00000051596	ENSG00000132535
Uniprot IDs		Q96J01	A0A3B3IS17 B7Z4H2 B7Z647 B9EGL1 P78352
PDB IDs		7APK 7ZNK 7ZNL	1KEF 2MES 3I4W 3K82 3ZRT 5J7J 5JXB 6QJD 6QJF 6QJG 6QJI 6QJJ 6QJK 6QJL 6QJN 6SPV 6SPZ 8AH4 8AH5 8AH6 8AH7 8AH8
GO Terms Enriched among Interactors		Dendritic Spine Morphogenesis Identical Protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Neuron Projection Organization Modulation Of Excitatory Postsynaptic Potential Social Behavior Dendritic Spine Organization Postsynapse Organization P2Y1 Nucleotide Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Small Molecule Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein-containing Complex Assembly PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Thymidine Kinase Activity Cellular Component Assembly Beta-1 Adrenergic Receptor Binding Regulation Of Nervous System Process Regulation Of Grooming Behavior ATP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission DNA Synthesis Involved In Mitotic DNA Replication Execution Phase Of Necroptosis Protein-containing Complex Organization BRCA1-B Complex Cellular Response To Indole-3-methanol Negative Regulation Of Mitotic Cell Cycle Phase Transition AMPA Glutamate Receptor Clustering Dendritic Spine Neuroligin Family Protein Binding Fructose 2,6-bisphosphate Metabolic Process Fructose-2,6-bisphosphate 2-phosphatase Activity 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Thymidine Biosynthetic Process Negative Regulation Of Centriole Replication Negative Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex	Synapse Glutamatergic Synapse Postsynaptic Density Membrane Plasma Membrane Postsynaptic Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Regulation Of Membrane Potential Regulation Of Biological Quality Ionotropic Glutamate Receptor Signaling Pathway Membrane Regulation Of Signaling Regulation Of Cell Communication Scaffold Protein Binding Synaptic Signaling Chemical Synaptic Transmission Dendrite Regulation Of Synapse Organization Trans-synaptic Signaling Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Signaling Ligand-gated Ion Channel Signaling Pathway Metal Ion Transport Cell Communication Presynaptic Membrane NMDA Selective Glutamate Receptor Complex PDZ Domain Binding Monoatomic Cation Transport Monoatomic Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Transmission, Glutamatergic Regulation Of System Process Cell-cell Signaling NMDA Glutamate Receptor Activity Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Dendritic Spine Signal Transduction Monoatomic Ion Channel Activity Protein Localization To Synapse Synaptic Transmission, Glutamatergic Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Monoatomic Ion Channel Complex Regulation Of Transport Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Regulation Of Synapse Assembly