BFAR and UBE2K

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		BFAR	UBE2K
Description		bifunctional apoptosis regulator	ubiquitin conjugating enzyme E2 K
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Filopodium Tip
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Caspase Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of IRE1-mediated Unfolded Protein Response	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)
Interacting Genes		12 interacting genes: BCL2 CASP10 CASP8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2N UBE2U UBE2W	98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		51283	3093
HPRD ID		16548	04165
Ensembl ID		ENSG00000103429	ENSG00000078140
Uniprot IDs		H3BMP2 Q9NZS9	B3KSH4 B4DIZ2 P61086
PDB IDs			1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Protein K48-linked Ubiquitination Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Cellular Response To Nutrient Levels Nucleotide Binding Transferase Activity Macromolecule Metabolic Process Death Effector Domain Binding Protein K11-linked Ubiquitination Regulation Of TOR Signaling Protein Catabolic Process Ripoptosome CD95 Death-inducing Signaling Complex Protein Monoubiquitination Negative Regulation Of Intracellular Signal Transduction Response To Nutrient Levels Negative Regulation Of Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Protein K6-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Protein-containing Complex DNA Damage Response	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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