NFKBIL1 and ADIPOR1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NFKBIL1	ADIPOR1
Description		NFKB inhibitor like 1	adiponectin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Plasma Membrane Membrane
	Molecular Function	Protein Binding Transcription Regulator Inhibitor Activity	Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide	Lipid Metabolic Process Fatty Acid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Negative Regulation Of Cell Growth Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Glucose Homeostasis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			AMPK inhibits chREBP transcriptional activation activity
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 23128233) Early chronic obstructive pulmonary disease in never smokers ( 33235445) Eosinophil count ( 32888494) Glycated hemoglobin levels ( 34059833) Height ( 28552196) Hematocrit ( 32888494) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Neonatal lupus ( 20662065) Refractive error ( 32231278) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sepsis (90-day mortality) ( 32592749) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Type 2 diabetes ( 30054458) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Mean platelet volume ( 27863252 32888494)
Interacting Genes		6 interacting genes: ADIPOR1 AKAP19 CASP10 CLEC18C NME7 PEX14	6 interacting genes: APPL1 DPH3 NAA20 NFKBIL1 STK11 TBXA2R
Entrez ID		4795	51094
HPRD ID		07043	06402
Ensembl ID		ENSG00000204498	ENSG00000159346
Uniprot IDs		A0A0A0MRT5 A8K778 Q5STV6 Q9UBC1	Q96A54
PDB IDs			5LXG 6KRZ 6KS0
Enriched GO Terms of Interacting Partners?			Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-terminal Peptidyl-glutamine Acetylation NatB Complex N-terminal Peptidyl-aspartic Acid Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Intracellular Protein-containing Complex Protein N-terminal-methionine Acetyltransferase Activity TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Iron Chaperone Activity Protein Localization To Organelle Positive Regulation Of Vesicle Transport Along Microtubule Cellular Response To Lipopolysaccharide LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Protein Localization To Nucleus Macropinosome Protein-N-terminal Amino-acid Acetyltransferase Activity
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