RHBDD1 and TGFA

Number of citations of the paper that reports this interaction (PubMedID 26300397)
47

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RHBDD1	TGFA
Description		rhomboid domain containing 1	transforming growth factor alpha
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Proteolysis Apoptotic Process Spermatogenesis Positive Regulation Of Protein Processing Cell Differentiation Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Spermatid Differentiation Positive Regulation Of Secretion Positive Regulation Of Protein Metabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Angiogenesis Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Intracellular Signal Transduction ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Mammary Gland Alveolus Development Hepatocyte Proliferation
Pathways			PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Gastric cancer
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)	Acne (severe) ( 24927181) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Hair shape ( 29220522) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Hip minimal joint space width ( 27701424) Longevity ( 20834067) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Low hand grip strength (60 years and older) (FNIH) ( 33510174) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Osteoarthritis ( 30664745) Pulse pressure in young-onset hypertension ( 24892410) Response to citalopram or escitalopram in depression ( 27622933) Response to esketamine in treatment resistant depression ( 32724131) Severe progression in rheumatoid arthritis ( 29065906) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		21 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC ITCH LPCAT2 LRRK2 MFHAS1 NEDD4 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE	17 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDD1 RHBDF1 SDCBP SGTA SNTA1
Entrez ID		84236	7039
HPRD ID		13206	07522
Ensembl ID		ENSG00000144468	ENSG00000163235
Uniprot IDs		Q8TEB9	E7EPT6 F8VNR3 P01135
PDB IDs		5EPP	1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5 7SZ5 7SZ7
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Autophagy Endoplasmic Reticulum Membrane Regulation Of Autophagosome Assembly Endoplasmic Reticulum Regulation Of Vacuole Organization Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagosome Assembly Positive Regulation Of Protein Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Syntaxin-1 Binding Ubiquitin-protein Transferase Activity Ether Lipid Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Catabolic Process Negative Regulation Of Macroautophagy 3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly D-lysine 5,6-aminomutase Activity Channel Inhibitor Activity Regulation Of Macroautophagy Protein Monoubiquitination Lumenal Side Of Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Macrophage Activation Plasmalogen Synthase Activity Organelle Subcompartment Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity	Localization Within Membrane Positive Regulation Of Growth Positive Regulation Of Cell Growth Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endopeptidase Activity Establishment Of Protein Localization To Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Membrane Membrane Protein Proteolysis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation ERBB2-ERBB4 Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Growth Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cell Migration Regulation Of Signal Transduction Golgi Membrane Regulation Of Protein Catabolic Process Metallodipeptidase Activity ERBB2-EGFR Signaling Pathway Regulation Of Cell Motility Regulation Of Cell Growth ERBB4 Signaling Pathway Basal Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Neuromuscular Junction Positive Regulation Of Protein Phosphorylation ATPase Binding Regulation Of Cell Communication Regulation Of Signaling Basolateral Plasma Membrane Positive Regulation Of T Cell Chemotaxis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of T Cell Chemotaxis
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