RHBDD1 and SEC22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHBDD1	SEC22B
Description		rhomboid domain containing 1	SEC22 homolog B, vesicle trafficking protein
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	SNAP Receptor Activity Protein Binding
	Biological Process	Proteolysis Apoptotic Process Spermatogenesis Positive Regulation Of Protein Processing Cell Differentiation Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Spermatid Differentiation Positive Regulation Of Secretion Positive Regulation Of Protein Metabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly
Pathways			ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)	Iris color (L* coordinate) ( 30895295)
Interacting Genes		21 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC ITCH LPCAT2 LRRK2 MFHAS1 NEDD4 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE	57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		84236	9554
HPRD ID		13206	04939
Ensembl ID		ENSG00000144468	ENSG00000265808
Uniprot IDs		Q8TEB9	O75396
PDB IDs		5EPP	2NUP 2NUT 3EGD 3EGX 8HR0
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Negative Regulation Of Autophagy Endoplasmic Reticulum Membrane Regulation Of Autophagosome Assembly Endoplasmic Reticulum Regulation Of Vacuole Organization Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Negative Regulation Of Autophagosome Assembly Positive Regulation Of Protein Catabolic Process Phosphatidylcholine Acyl-chain Remodeling Membrane Syntaxin-1 Binding Ubiquitin-protein Transferase Activity Ether Lipid Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Neuromuscular Junction Development Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of Catabolic Process Negative Regulation Of Macroautophagy 3-beta-hydroxysteroid Dehydrogenase [NAD(P)+]/C4-decarboxylase Activity 3-beta-hydroxysteroid Dehydrogenase (NAD+)/C4-decarboxylase Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly D-lysine 5,6-aminomutase Activity Channel Inhibitor Activity Regulation Of Macroautophagy Protein Monoubiquitination Lumenal Side Of Lysosomal Membrane ER To Golgi Transport Vesicle Membrane Regulation Of Macrophage Activation Plasmalogen Synthase Activity Organelle Subcompartment Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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