CIAO2A and SIN3A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIAO2A	SIN3A
Description		cytosolic iron-sulfur assembly component 2A	SIN3 transcription regulator family member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytosolic [4Fe-4S] Assembly Targeting Complex	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Transcription Repressor Complex Protein-containing Complex Sin3-type Complex
	Molecular Function	Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Chromosome Segregation Protein Maturation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Regulation Of DNA-templated Transcription Intracellular Protein Localization Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cerebral Cortex Neuron Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Heterochromatin Formation Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Rhythmic Process Response To Methylglyoxal Type I Interferon-mediated Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Tert-butyl Hydroperoxide Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine
Pathways			SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Caffeine consumption from tea ( 33287642) Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)
Interacting Genes		25 interacting genes: AGTRAP APOA2 CIAO1 CMTM6 CREB3L1 DERL1 DGAT2L6 EBAG9 ERGIC3 FKBP7 GJA8 GSC2 KCNIP1 LIME1 MEST PLP2 PLPP6 PLPPR2 PRAF2 RHBDD2 SETD4 SIN3A TMED8 TNFRSF10D VAMP3	101 interacting genes: ARID4A ARID4B ATM BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CEBPA CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 DMRTC1B ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB1 PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 TSN ZBTB16
Entrez ID		84191	25942
HPRD ID		08010	09690
Ensembl ID		ENSG00000166797	ENSG00000169375
Uniprot IDs		Q9H5X1	Q96ST3
PDB IDs		2M5H 3UX2 3UX3
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Signal Recognition Particle Binding Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Phosphatidate Phosphatase Activity	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process DNA Binding Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Sin3-type Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Remodeling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Repressor Complex Epigenetic Regulation Of Gene Expression Transcription Corepressor Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?