CIAO2A and APOA2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CIAO2A	APOA2
Name		cytosolic iron-sulfur assembly component 2A	apolipoprotein A2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytosolic [4Fe-4S] Assembly Targeting Complex	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Metal Ion Binding	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Chromosome Segregation Protein Maturation	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways		None	PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		None	Zinc Copper Zinc acetate
Diseases		None	Familial amyloidosis
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		25 interacting genes: AGTRAP APOA2 CIAO1 CMTM6 CREB3L1 DERL1 DGAT2L6 EBAG9 ERGIC3 FKBP7 GJA8 GSC2 KCNIP1 LIME1 MEST PLP2 PLPP6 PLPPR2 PRAF2 RHBDD2 SETD4 SIN3A TMED8 TNFRSF10D VAMP3	31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1
Entrez ID		84191	336
HPRD ID		08010	00129
Ensembl ID		ENSG00000166797	ENSG00000158874
Uniprot IDs		Q9H5X1	P02652
PDB IDs		2M5H 3UX2 3UX3	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Signal Recognition Particle Binding Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Phosphatidate Phosphatase Activity	Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process