FAM161A and WDPCP

		FAM161A	WDPCP
Description		FAM161 centrosomal protein A	WD repeat containing planar cell polarity effector
Image		No pdb structure
GO Annotations	Cellular Component	Astral Microtubule Photoreceptor Inner Segment Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Spindle Microtubule Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Mitotic Spindle Mitotic Spindle Pole	Cytoplasm Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Membrane Apical Plasma Membrane Cell Projection Axonemal Basal Plate
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding	Phosphatidylinositol Binding
	Biological Process	Visual Perception Cell Projection Organization Cilium Organization Cilium Assembly	Establishment Of Planar Polarity Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Neural Tube Development Cell Projection Organization Septin Cytoskeleton Organization Regulation Of Protein Localization Intraciliary Transport Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Embryonic Organ Development Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Podocyte Cell Migration Regulation Of Ruffle Assembly Regulation Of Cilium Assembly Regulation Of Establishment Of Cell Polarity
Pathways
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Atrial fibrillation ( 29892015) Erectile dysfunction ( 30583798) Systemic lupus erythematosus ( 28714469)	Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		139 interacting genes: AQP1 AXIN2 BACH2 BEGAIN BEND3 BEND5 BICD2 BRCA1 CADPS CALCOCO1 CALCOCO2 CARD9 CBY2 CCDC102B CCDC125 CCDC13 CCDC136 CCDC185 CCDC33 CCDC57 CCDC88B CCNC CCNDBP1 CDR2 CDR2L CEP44 CEP57L1 CEP63 CEP70 CEP72 CTNNA3 DHX32 DOCK8 DRC4 DVL2 EHMT2 EVI5 FAM9B FSD2 FXR1 GOLGA2 GOLGA6L9 GPBP1 GPRASP3 GRIPAP1 HEXIM2 HMBOX1 HOOK1 HOOK2 IKZF1 INO80E JRK KANK2 KASH5 KAT5 KDM1A KIAA0753 KIAA1328 KIFC3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP5-7 KRTAP5-9 LDOC1 LMNA LURAP1L LZTS1 LZTS2 MAGEA11 MCC MCM6 MDFI MID2 MIPOL1 MKRN1 MTCL2 MTUS2 NECAB2 NINL NUTM1 OSBPL3 PDE4DIP PHC2 PIBF1 PICK1 PLEKHG4 PNMA1 PNMA2 POC5 PPFIA1 PPM1F PPP2R3C PRKAR1B QARS1 RINT1 ROPN1 RUBCN RUNDC3A SCNM1 SMARCD1 SSX2IP STX11 SYCE1 TAX1BP1 TBC1D1 TFIP11 TMCC2 TNIP1 TNIP3 TRAF1 TRAF2 TRIB3 TRIM15 TRIM27 TRIM37 TRIM41 TRIM54 TRIM69 TSGA10 TXLNB VIM VPS52 ZBTB1 ZBTB14 ZBTB43 ZBTB8A ZIM2 ZNF24 ZNF250 ZNF276 ZNF426 ZNF526 ZNF792 ZRANB1 ZSCAN12
Entrez ID		84140	51057
HPRD ID		18996	14228
Ensembl ID		ENSG00000170264	ENSG00000143951
Uniprot IDs		Q3B820	O95876
PDB IDs			7Q3D
Enriched GO Terms of Interacting Partners?		Protein Binding Microtubule-based Process Identical Protein Binding Centrosome Microtubule Organizing Center Organization Microtubule Cytoskeleton Organization Cytoskeleton Intermediate Filament Centriole Replication Cytoplasm Centrosome Cycle Centriole Assembly Cytoskeleton Organization Microtubule Binding Cytoplasmic Microtubule Organization Response To Muramyl Dipeptide Microtubule Organelle Organization Negative Regulation Of RNA Metabolic Process Cellular Response To Muramyl Dipeptide Dynein Light Intermediate Chain Binding Zinc Ion Binding Regulation Of Organelle Organization Membraneless Organelle Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centriolar Satellite Keratin Filament Cytosol Microtubule Organizing Center Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Organelle Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Suppression Of Viral Release By Host Centriole Negative Regulation Of Fatty Acid Biosynthetic Process Transcription Coactivator Activity Nuclear Pore Localization FHF Complex Ubiquitin Protein Ligase Activity Protein Localization To Cytoskeleton Nucleus	Calcium-dependent Protein Serine/threonine Phosphatase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Regulation Of Protein Stability Astral Microtubule Nuclear Polyadenylation-dependent MRNA Catabolic Process RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin Complex ScaRNA Localization To Cajal Body N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Mitochondrial MRNA Polyadenylation Mitochondrial RNA 3'-end Processing Exoribonuclease Complex RNA Import Into Mitochondrion Positive Regulation Of MiRNA Catabolic Process Mitochondrial RNA 5'-end Processing Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels
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