WDPCP

Description		WD repeat containing planar cell polarity effector
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Membrane Apical Plasma Membrane Cell Projection Axonemal Basal Plate
	Molecular Function	Phosphatidylinositol Binding
	Biological Process	Establishment Of Planar Polarity Kidney Development Auditory Receptor Cell Morphogenesis Smoothened Signaling Pathway Nervous System Development Regulation Of Fibroblast Migration Regulation Of Embryonic Cell Shape Neural Tube Development Cell Projection Organization Septin Cytoskeleton Organization Regulation Of Protein Localization Intraciliary Transport Embryonic Digit Morphogenesis Camera-type Eye Development Tongue Morphogenesis Cilium Organization Establishment Of Protein Localization Embryonic Organ Development Regulation Of Focal Adhesion Assembly Digestive System Development Roof Of Mouth Development Cilium Assembly Respiratory System Development Circulatory System Development Podocyte Cell Migration Regulation Of Ruffle Assembly Regulation Of Cilium Assembly Regulation Of Establishment Of Cell Polarity
Pathways
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Anxiety ( 33859377) Asthma and attention deficit hyperactivity disorder ( 31619474) Childhood ear infection ( 27182965) Cutaneous malignant melanoma ( 26237428) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Prostate cancer ( 31562322) Regular attendance at a religious group ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Novel Interacting Genes		9 novel interacting genes: AHSA2P B3GNT2 CCT4 COMMD1 EHBP1 FAM161A PNPT1 PPP3R1 USP34
Interacting Genes
Entrez ID		51057
HPRD ID		14228
Ensembl ID		ENSG00000143951
Uniprot IDs		O95876
PDB IDs		7Q3D
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Serine/threonine Phosphatase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cytosol Regulation Of Protein Stability Astral Microtubule Nuclear Polyadenylation-dependent MRNA Catabolic Process RRNA Transport RRNA Import Into Mitochondrion Positive Regulation Of Mitochondrial RNA Catabolic Process Mitochondrial Degradosome Mitochondrial MRNA Catabolic Process Polyribonucleotide Nucleotidyltransferase Activity Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin Complex ScaRNA Localization To Cajal Body N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Mitochondrial MRNA Polyadenylation Mitochondrial RNA 3'-end Processing Exoribonuclease Complex RNA Import Into Mitochondrion Positive Regulation Of MiRNA Catabolic Process Mitochondrial RNA 5'-end Processing Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels
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