METTL21A and ARPC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		METTL21A	ARPC4
Description		methyltransferase 21A, HSPA lysine	actin related protein 2/3 complex subunit 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Actin Cytoskeleton Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Methyltransferase Activity Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	Protein Methylation Methylation Negative Regulation Of Protein Folding	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation
Pathways		Protein methylation	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		14 interacting genes: ARPC4 ATRIP FAM200C HSPA1A HSPA5 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZNF620 ZNF655 ZRANB1	13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL
Entrez ID		151194	10093
HPRD ID		14090	10368
Ensembl ID		ENSG00000144401	ENSG00000241553
Uniprot IDs		C9JES0 H7BXH9 Q8WXB1	P59998
PDB IDs		4LEC	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?			Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Actin Filament Organization Actin Cytoskeleton Actin Binding Structural Constituent Of Cytoskeleton Supramolecular Fiber Organization Actin Filament Binding Site Of Double-strand Break Focal Adhesion Actin Polymerization-dependent Cell Motility Lamellipodium Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Meiotic Chromosome Movement Towards Spindle Pole Regulation Of Actin Filament Polymerization Positive Regulation Of Lamellipodium Organization Cytoskeleton Actin Cap Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Spindle Localization Meiotic Cytokinesis Regulation Of Cell Projection Assembly Extracellular Exosome Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Asymmetric Cell Division Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Regulation Of Protein-containing Complex Assembly Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cytoskeleton Organization Cell Motility Growth Cone Leading Edge Tubulobulbar Complex Actin Polymerization Or Depolymerization Cell Leading Edge Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Cellular Response To Type II Interferon Negative Regulation Of Membrane Tubulation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?