ENKD1 and DVL2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ENKD1	DVL2
Gene Name		enkurin domain containing 1	dishevelled segment polarity protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule Microtubule Cytoskeleton	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function		Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process		Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: APP BEGAIN CALCOCO2 CCDC102B CCDC136 CCDC85B CDR2 CEP70 DGCR6 DVL2 DVL3 FAM102A KRTAP10-5 MDFI MIPOL1 MKRN3 NBPF22P NEFL PDLIM7 PHC2 PLSCR1 PNMA1 PNMA2 PPP1CC RAD54B RBPMS SPERT SPSB3 TRAF2 TRGV7 TRIM54 TSC22D4 UBXN11 YWHAE ZBTB14	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		84080	1856
HPRD ID		13151	03690
Ensembl ID		ENSG00000124074	ENSG00000004975
Uniprot IDs		Q9H0I2	I3L2N2 O14641
PDB IDs			2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAP Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Protein Serine/threonine Kinase Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of MAP Kinase Activity Cochlea Morphogenesis Hippo Signaling Non-canonical Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Cochlea Development Positive Regulation Of Protein Kinase Activity Axon Cargo Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Response To Stress Regulation Of Protein Tyrosine Kinase Activity Outflow Tract Morphogenesis Regulation Of Phosphorylation Synaptic Growth At Neuromuscular Junction Regulation Of Heart Rate By Hormone Negative Regulation Of Peptidyl-serine Dephosphorylation Positive Regulation Of Protein Modification Process Regulation Of Binding Positive Regulation Of Transferase Activity Neuromuscular Process Controlling Balance Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Neurofilament Bundle Assembly Collateral Sprouting In Absence Of Injury Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signaling	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?			adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?			adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Intersection) ?