ENKD1 and DVL3

Number of citations of the paper that reports this interaction (PMID 19447967)
10

Data Source:
BioGRID (two hybrid)

		ENKD1	DVL3
Gene Name		enkurin domain containing 1	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule Microtubule Cytoskeleton	Cytosol
	Molecular Function		Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process		Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		35 interactors: APP BEGAIN CALCOCO2 CCDC102B CCDC136 CCDC85B CDR2 CEP70 DGCR6 DVL2 DVL3 FAM102A KRTAP10-5 MDFI MIPOL1 MKRN3 NBPF22P NEFL PDLIM7 PHC2 PLSCR1 PNMA1 PNMA2 PPP1CC RAD54B RBPMS SPERT SPSB3 TRAF2 TRGV7 TRIM54 TSC22D4 UBXN11 YWHAE ZBTB14	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		84080	1857
HPRD ID		13151	03222
Ensembl ID		ENSG00000124074	ENSG00000161202
Uniprot IDs		Q9H0I2	Q92997
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAP Kinase Activity Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Protein Serine/threonine Kinase Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of MAP Kinase Activity Cochlea Morphogenesis Hippo Signaling Non-canonical Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Cochlea Development Positive Regulation Of Protein Kinase Activity Axon Cargo Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Response To Stress Regulation Of Protein Tyrosine Kinase Activity Outflow Tract Morphogenesis Regulation Of Phosphorylation Synaptic Growth At Neuromuscular Junction Regulation Of Heart Rate By Hormone Negative Regulation Of Peptidyl-serine Dephosphorylation Positive Regulation Of Protein Modification Process Regulation Of Binding Positive Regulation Of Transferase Activity Neuromuscular Process Controlling Balance Convergent Extension Involved In Neural Plate Elongation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Neurofilament Bundle Assembly Collateral Sprouting In Absence Of Injury Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Signaling	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?