KREMEN1 and DKK1

Number of citations of the paper that reports this interaction (PMID 12050670)
170

Data Source:
HPRD (in vitro, in vivo)

		KREMEN1	DKK1
Gene Name		kringle containing transmembrane protein 1	dickkopf WNT signaling pathway inhibitor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Signal Transducer Activity Protein Binding Growth Factor Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cell Communication Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Endoderm Formation Mesoderm Formation Hair Follicle Development Regulation Of Receptor Internalization Negative Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of BMP Signaling Pathway Forebrain Development Negative Regulation Of Protein Complex Assembly Response To Retinoic Acid Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Skeletal Muscle Tissue Development Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)	Electrocardiographic traits ( 20062063) Ventricular conduction ( 21076409)
Protein-Protein Interactions		1 interactors: DKK1	7 interactors: DPP4 KREMEN1 KRTAP10-1 LRP5 LRP6 MDFI SMAD9
Entrez ID		83999	22943
HPRD ID		11182	05544
Ensembl ID		ENSG00000183762	ENSG00000107984
Uniprot IDs		Q96MU8	I1W660 O94907
PDB IDs			3S2K 3S8V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Endodermal Cell Fate Specification Negative Regulation Of Mesodermal Cell Fate Specification Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Negative Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Fate Specification Negative Regulation Of Mesoderm Development Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Extracellular Negative Regulation Of Signal Transduction Regulation Of Cell Fate Specification Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Receptor Activity Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Regulation Of Receptor Internalization Regulation Of Cell Fate Commitment Regulation Of Gastrulation Face Morphogenesis Head Morphogenesis Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Face Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Endoderm Formation Body Morphogenesis Regulation Of Cardiac Muscle Tissue Development Regulation Of Skeletal Muscle Tissue Development Regulation Of BMP Signaling Pathway Somitogenesis Endoderm Development Mesoderm Formation Mesoderm Morphogenesis Hair Follicle Development Hair Cycle Process Somite Development Regulation Of Striated Muscle Cell Differentiation Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Hair Cycle Regulation Of Embryonic Development Segmentation	Dorsal/ventral Axis Specification Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Wnt Signaling Pathway Axis Specification Dorsal/ventral Pattern Formation Embryonic Retina Morphogenesis In Camera-type Eye Skeletal System Development Cell Migration Involved In Gastrulation Anatomical Structure Regression Ameboidal-type Cell Migration Regulation Of Canonical Wnt Signaling Pathway Bone Development Connective Tissue Development Skeletal System Morphogenesis Wnt Signaling Pathway Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Embryonic Organ Morphogenesis Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Embryonic Camera-type Eye Development Mammary Gland Duct Morphogenesis Regulation Of Tissue Remodeling Embryonic Digit Morphogenesis Positive Regulation Of Stem Cell Proliferation Pattern Specification Process Embryonic Organ Development Mammary Gland Morphogenesis Midbrain Development Canonical Wnt Signaling Pathway Mammary Gland Epithelium Development Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Regulation Of Stem Cell Proliferation Tissue Remodeling Embryonic Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Bone Morphogenesis Regulation Of Fat Cell Differentiation
Tagcloud ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize znrf3	abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Difference) ?		22q12 5p15 acc accs adrenocortical cdc27 cna cnas corroborate ctnnb1 denote exclusive exome gnas homozygous incompletely mutually nf2 ontology rb1 recurrently repressors scn7a sdk1 somatic synonymous tert utilize znrf3	abcb1b administrated brosis colla1 corroborated dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt2 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a
Tagcloud (Intersection) ?