KREMEN1

Description		kringle containing transmembrane protein 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Apoptotic Process Cell Communication Signal Transduction Wnt Signaling Pathway Negative Regulation Of Ossification Negative Regulation Of Axon Regeneration Limb Development Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by LRP5 mutants
Drugs
Diseases
GWAS		Birth weight ( 27680694 31043758) Blood protein levels ( 30072576) Heel bone mineral density ( 28869591 30598549) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Pancreatic cancer ( 25086665) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		1 interacting genes: DKK1
Entrez ID		83999
HPRD ID		11182
Ensembl ID		ENSG00000183762
Uniprot IDs		Q96MU8
PDB IDs		5FWS 5FWT 5FWU 5FWV 5FWW 7BZT 7BZU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Presynapse Assembly Positive Regulation Of Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Wnt-Frizzled-LRP5/6 Complex Assembly Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Mesodermal Cell Fate Specification Positive Regulation Of Dopaminergic Neuron Differentiation Regulation Of Endodermal Cell Fate Specification Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Mesodermal Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Heart Induction Head Morphogenesis Negative Regulation Of Synapse Assembly Regulation Of Heart Morphogenesis Motor Learning Synapse Pruning Negative Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Fate Commitment Receptor Antagonist Activity Co-receptor Binding Regulation Of Dopaminergic Neuron Differentiation Negative Regulation Of Cardiocyte Differentiation Endocardial Cushion Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Endoderm Formation Negative Regulation Of Synapse Organization Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Differentiation Heart Valve Development Regulation Of Presynapse Assembly Low-density Lipoprotein Particle Receptor Binding Organ Induction Regulation Of Presynapse Organization Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Animal Organ Formation Negative Regulation Of SMAD Protein Signal Transduction Developmental Induction Face Morphogenesis Endoderm Development Negative Regulation Of Striated Muscle Cell Differentiation Hair Follicle Development Negative Regulation Of Ossification Regulation Of Cell Fate Commitment Mesoderm Formation Limb Development Mesenchyme Development Formation Of Primary Germ Layer Negative Regulation Of BMP Signaling Pathway
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