RORA and SMARCD3

Number of citations of the paper that reports this interaction (PMID 14701856)
44

Data Source:
HPRD (in vitro)

		RORA	SMARCD3
Gene Name		RAR-related orphan receptor A	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex NpBAF Complex NBAF Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity	Transcription Coactivator Activity Receptor Binding Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding
	Biological Process	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Gene Expression Positive Regulation Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Hypoxia T-helper 17 Cell Differentiation Regulation Of Cholesterol Homeostasis	Positive Regulation Of Neuroblast Proliferation Secondary Heart Field Specification Cardiac Right Ventricle Formation Neural Retina Development Nucleosome Disassembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Muscle Cell Differentiation Regulation Of Protein Binding Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis RMTs methylate histone arginines Regulation of cholesterol biosynthesis by SREBP (SREBF) Chromatin modifying enzymes Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS		Asthma ( 20860503) Breast cancer (prognosis) ( 23319801) C-reactive protein ( 21300955) Depression (quantitative trait) ( 20800221) Gamma gluatamyl transferase levels ( 22010049) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Menarche (age at onset) ( 21102462 23599027) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume ( 21116278)	IgG glycosylation ( 23382691)
Protein-Protein Interactions		20 interactors: COPS5 EIF3I EP300 GFAP LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 ZXDC	18 interactors: ARHGAP1 CCNE1 ESR1 ESRRA FANCA JUN MAPK14 NR1H4 NR5A1 NR5A2 PBX1 PPARG RARA RORA RXRA SMARCC1 SREBF1 STARD13
Entrez ID		6095	6604
HPRD ID		02896	03440
Ensembl ID		ENSG00000069667	ENSG00000082014
Uniprot IDs		F1DAL0 P35398	Q6STE5
PDB IDs		1N83 1S0X
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Cellular Metabolic Process Limbic System Development Peptidyl-lysine Modification Response To Steroid Hormone Regulation Of Cell Differentiation Histone Acetylation Positive Regulation Of Cell Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Cell Development Protein Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Chromatin Modification Response To Hormone Positive Regulation Of Epithelial Cell Proliferation Histone H4 Acetylation Histone Modification Regulation Of Neurogenesis	Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Hormone-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Gene Expression Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cellular Response To Hormone Stimulus Response To Lipid Positive Regulation Of Metabolic Process Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process System Development Signal Transduction Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stimulus Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Signaling Cell Communication Multicellular Organismal Development Biosynthetic Process Steroid Metabolic Process Regulation Of Gene Expression Anatomical Structure Development
Tagcloud ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Difference) ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico subpopulations trithorax
Tagcloud (Intersection) ?