RORA and PNRC2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RORA	PNRC2
Gene Name		RAR-related orphan receptor A	proline-rich nuclear receptor coactivator 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasmic MRNA Processing Body Nucleus
	Molecular Function	Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity	Protein Binding
	Biological Process	Angiogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Gene Expression Positive Regulation Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter CGMP Metabolic Process Negative Regulation Of Inflammatory Response Regulation Of Transcription Involved In Cell Fate Commitment Triglyceride Homeostasis Cellular Response To Hypoxia T-helper 17 Cell Differentiation Regulation Of Cholesterol Homeostasis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Transcription, DNA-templated Regulation Of Transcription, DNA-templated Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Nuclear Receptor transcription pathway Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS		Asthma ( 20860503) Breast cancer (prognosis) ( 23319801) C-reactive protein ( 21300955) Depression (quantitative trait) ( 20800221) Gamma gluatamyl transferase levels ( 22010049) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Menarche (age at onset) ( 21102462 23599027) Pulmonary function decline ( 22424883) Response to citalopram treatment ( 19846067) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume ( 21116278)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: COPS5 EIF3I EP300 GFAP LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 ZXDC	20 interactors: AR DCP1A ESR1 ESR2 ESRRA ESRRG GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SF1 SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		6095	55629
HPRD ID		02896	17871
Ensembl ID		ENSG00000069667	ENSG00000189266
Uniprot IDs		F1DAL0 P35398	Q9NPJ4
PDB IDs		1N83 1S0X	4B6H
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Cellular Metabolic Process Limbic System Development Peptidyl-lysine Modification Response To Steroid Hormone Regulation Of Cell Differentiation Histone Acetylation Positive Regulation Of Cell Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Cell Development Protein Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Chromatin Modification Response To Hormone Positive Regulation Of Epithelial Cell Proliferation Histone H4 Acetylation Histone Modification Regulation Of Neurogenesis	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Organ Development Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Developmental Process Involved In Reproduction Prostate Gland Development Sex Differentiation Multicellular Organismal Development Anatomical Structure Development Regulation Of Metabolic Process
Tagcloud ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions
Tagcloud (Difference) ?		15q21 backcross cdna chromosomal chromosome clone fluorescence hybridization interspecific map mapped member mouse partial places pml promyelocytic proximity q22 rara reciprocal retinoid situ steroid superfamily thyroid translocation unique	2d af alternatives biologically circular coactivators cognate competitive confirms constitutes coregulator coregulators dichroism ecd eralpha eralpha17p exception exhaustive governing grb2 issued motifs polyproline ppii pxxp sh3 spectroscopy transductions
Tagcloud (Intersection) ?