ATG10 and ATG12

Number of citations of the paper that reports this interaction (PMID 12482611)
10

Data Source:
HPRD (in vitro, in vivo)

		ATG10	ATG12
Gene Name		autophagy related 10	autophagy related 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm	Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex
	Molecular Function	Ligase Activity Atg12 Transferase Activity	Protein Binding Atg8 Ligase Activity
	Biological Process	Protein Lipidation Autophagy Protein Transport Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Autophagy In Response To ER Overload	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Cellular Response To Nitrogen Starvation Negative Regulation Of Type I Interferon Production Nucleophagy Innate Immune Response
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ATG12 ATG5 ATG7	10 interactors: APP ATG10 ATG3 ATG5 ATG7 CRX KRTAP4-12 MDFI PLSCR1 PTK2
Entrez ID		83734	9140
HPRD ID		16497	08496
Ensembl ID		ENSG00000152348	ENSG00000145782
Uniprot IDs		Q9H0Y0	O94817
PDB IDs			4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Nucleophagy C-terminal Protein Lipidation Mitochondrion Degradation Organelle Disassembly Negative Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Histone H4 Acetylation Protein Lipidation Lipoprotein Biosynthetic Process Negative Stranded Viral RNA Replication Cellular Response To Starvation Autophagy Lipoprotein Metabolic Process Response To Starvation Cellular Response To Nutrient Levels Regulation Of Histone H4 Acetylation Positive Regulation Of Mucus Secretion Post-translational Protein Modification Cellular Response To Extracellular Stimulus Regulation Of Mucus Secretion Negative Regulation Of Histone Acetylation Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Viral Genome Replication Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Autophagic Vacuole Assembly Regulation Of Histone Acetylation Negative Regulation Of Type I Interferon Production Macroautophagy Cardiac Muscle Cell Development Negative Regulation Of Chromosome Organization Vacuole Organization Cardiac Muscle Cell Differentiation Regulation Of Type I Interferon Production Regulation Of Histone Modification Cardiocyte Differentiation Striated Muscle Cell Development Muscle Cell Development Viral Life Cycle Cardiac Muscle Tissue Development Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Negative Regulation Of Cytokine Production Late Nucleophagy Piecemeal Microautophagy Of Nucleus Striated Muscle Cell Differentiation Cellular Response To Stress Catabolic Process	Nucleophagy Negative Regulation Of Histone H4-K16 Acetylation Mitochondrion Degradation Autophagy Organelle Disassembly Negative Regulation Of Histone H4 Acetylation Response To Stress Negative Stranded Viral RNA Replication Positive Regulation Of Cellular Metabolic Process Protein Lipidation Positive Regulation Of Mucus Secretion Regulation Of Histone H4 Acetylation Lipoprotein Biosynthetic Process Regulation Of Mucus Secretion Apoptotic Process Response To External Stimulus Negative Regulation Of Histone Acetylation Programmed Cell Death Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cell Death Negative Regulation Of Peptidyl-lysine Acetylation Death Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Cellular Protein Metabolic Process Viral Genome Replication Regulation Of Cilium Assembly Lipoprotein Metabolic Process Response To Starvation Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Platelet Activation C-terminal Protein Lipidation Cellular Response To Extracellular Stimulus Response To Stimulus Cellular Response To Stress Autophagic Vacuole Assembly Regulation Of Histone Acetylation Central Nervous System Neuron Axonogenesis Macroautophagy Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Organ Development Cardiac Muscle Cell Development Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		anchorage autophagic autophagy colon colony driven embryonic ex fully homeostasis ink4a lysosomal maintaining notably p16 p21 phenomena pluripotent restored senescence ser15 sox2 states stem stemness suppressors treat understood vacuole	akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		anchorage colon colony driven embryonic ex fully homeostasis ink4a lysosomal maintaining notably p16 p21 phenomena pluripotent restored senescence ser15 sox2 states stem stemness suppressors treat understood vacuole	akt1 antipsychotic atg4b atg5 atg7 autophagosome autophagosomes bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?		autophagic autophagy