ATG10 and IRGM

Number of citations of the paper that reports this interaction (PubMedID 22174682)
49

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ATG10	IRGM
Description		autophagy related 10	immunity related GTPase M
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Cell Projection
	Molecular Function	Protein Binding Transferase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Atg12 Conjugating Enzyme Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding Cardiolipin Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy ER Overload Response Protein Transport Protein Modification By Small Protein Conjugation	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Immune System Process Autophagy Inflammatory Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Catabolic Process Protein Destabilization Negative Regulation Of Type I Interferon Production Negative Regulation Of Type II Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Fission Autophagosome Maturation Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Autophagosome Maturation Positive Regulation Of Mitophagy Positive Regulation Of Xenophagy Positive Regulation Of Lysosome Organization
Pathways		Macroautophagy Macroautophagy
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Airway imaging phenotypes ( 26030696) Breast cancer ( 25751625 29059683) Carotid intima media thickness (mean) ( 31801372) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels in HIV infection ( 33109212)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 17554300 18587394 21102463 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		4 interacting genes: ATG12 ATG5 ATG7 IRGM	10 interacting genes: ATG10 ATG5 CGAS MAP1LC3C NLRP3 NOD1 NOD2 RIGI SH3GLB1 TLR3
Entrez ID		83734	345611
HPRD ID		16497	19559
Ensembl ID		ENSG00000152348	ENSG00000237693
Uniprot IDs		Q9H0Y0	A1A4Y4
PDB IDs
Enriched GO Terms of Interacting Partners?		Autophagosome Organization Autophagosome Assembly Regulation Of Autophagosome Maturation Negative Regulation Of Defense Response To Virus Piecemeal Microautophagy Of The Nucleus Microautophagy Nucleophagy Vacuole Organization Positive Regulation Of Viral Translation Negative Regulation Of Type I Interferon Production Atg8-family Ligase Activity Autophagy Regulation Of Defense Response To Virus Autophagy Of Mitochondrion Atg12-Atg5-Atg16 Complex Phagocytic Vesicle Membrane Negative Regulation Of Innate Immune Response Cellular Response To Nitrogen Starvation Regulation Of Protein-containing Complex Disassembly Regulation Of Type I Interferon Production Transferase Complex Macroautophagy Regulation Of Macroautophagy Organelle Assembly Phagophore Assembly Site Membrane Negative Regulation Of Immune Response Protein Lipidation Negative Regulation Of Defense Response Cellular Component Assembly Negative Regulation Of Cytokine Production Autophagosome Maturation Autophagosome Membrane Regulation Of Autophagy Mitophagy Response To Virus Positive Regulation Of Viral Process Regulation Of Innate Immune Response Autophagosome Negative Regulation Of Immune System Process Atg8 Activating Enzyme Activity Atg12 Activating Enzyme Activity Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Axoneme Otolith Development C-terminal Protein Lipidation Regulation Of Viral Process Protein-containing Complex Disassembly Catabolic Process	Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Activity Autophagy Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response-activating Signaling Pathway Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Defense Response To Other Organism Response To Stress Activation Of Immune Response Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response Cellular Response To Exogenous DsRNA Regulation Of Dendritic Cell Cytokine Production Intracellular Receptor Signaling Pathway Peptidoglycan Binding Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Regulation Of Immune Response Cellular Response To DsRNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Effector Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Other Organism Positive Regulation Of Immune Response Detection Of Biotic Stimulus Regulation Of Type I Interferon Production Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Interleukin-6 Production Response To Exogenous DsRNA Response To Virus Response To External Biotic Stimulus Macroautophagy Defense Response Detection Of Virus Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy
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