RIOK1 and SETD7

Number of citations of the paper that reports this interaction (PubMedID 29384474)
43

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		RIOK1	SETD7
Description		RIO kinase 1	SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Protein Serine Kinase Activity	P53 Binding Chromatin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity
	Biological Process	Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing	Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Response To Ethanol Positive Regulation Of DNA-templated Transcription Heterochromatin Organization Response To Alcohol
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	PKMTs methylate histone lysines
Drugs		Fostamatinib	S-adenosyl-L-homocysteine
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Shigella-associated diarrhea ( 33649051)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Ferritin levels ( 33491795) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		7 interacting genes: APP FBXO6 G3BP2 KDM1A SETD7 UBC YWHAB	32 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 OGT OTUB1 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21 UBC
Entrez ID		83732	80854
HPRD ID		17978	16226
Ensembl ID		ENSG00000124784	ENSG00000145391
Uniprot IDs		Q9BRS2	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		4OTP 6G5I 6V0N 6ZV6 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7BOC	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Cellular Response To CAMP Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Response To CAMP Protein Modification Process Phosphoserine Residue Binding Response To Fungicide	Chromatin Organization Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Remodeling Protein-DNA Complex Assembly Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Promoter-specific Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Transcription Chromatin DNA Binding Regulation Of Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction
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