RIOK1 and FBXO6

Number of citations of the paper that reports this interaction (PubMedID 29384474)
43

Data Source:
BioGRID (unspecified method)

		RIOK1	FBXO6
Description		RIO kinase 1	F-box protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity
	Biological Process	Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing	DNA Damage Checkpoint Signaling DNA Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process DNA Damage Response Response To Unfolded Protein Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Shigella-associated diarrhea ( 33649051)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701)
Interacting Genes		7 interacting genes: APP FBXO6 G3BP2 KDM1A SETD7 UBC YWHAB	3 interacting genes: ORC4 RIOK1 SKP1
Entrez ID		83732	26270
HPRD ID		17978	07291
Ensembl ID		ENSG00000124784	ENSG00000116663
Uniprot IDs		Q9BRS2	Q9NRD1
PDB IDs		4OTP 6G5I 6V0N 6ZV6 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7BOC
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Cellular Response To CAMP Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Response To CAMP Protein Modification Process Phosphoserine Residue Binding Response To Fungicide	Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions F-box Domain Binding Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of RRNA Processing Methyltransferase Complex Ubiquitin Ligase Activator Activity Preribosome, Small Subunit Precursor Regulation Of RRNA Processing DNA Replication Origin Binding DNA Replication Initiation Maintenance Of Protein Location In Nucleus PcG Protein Complex Cullin Family Protein Binding Molecular Function Activator Activity Positive Regulation Of Epithelial Cell Apoptotic Process Maturation Of SSU-rRNA Maintenance Of Protein Localization In Organelle
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