SETD7 and KLF4

Number of citations of the paper that reports this interaction (PMID 25042802)
0

Data Source:
BioGRID (enzymatic study)

		SETD7	KLF4
Gene Name		SET domain containing (lysine methyltransferase) 7	Kruppel-like factor 4 (gut)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Nuclear Chromatin Nucleoplasm Transcription Factor Complex
	Molecular Function	P53 Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Recruiting Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Phosphatidylinositol 3-kinase Regulator Activity Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromatin Modification Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Heterochromatin Organization	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Epidermal Cell Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Muscle Hyperplasia Stem Cell Maintenance Post-embryonic Camera-type Eye Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Retinoic Acid Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Maintenance Post-embryonic Hemopoiesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Peptide Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Breast cancer ( 21263130) Prostate cancer ( 23023329)
Protein-Protein Interactions		24 interactors: A1BG DNMT1 E2F1 ESR1 H3F3A HCFC1 HIST1H3A HIST1H4A HIST2H3C HIST3H3 KLF4 L3MBTL1 NR2F2 PPP1R12A PRKAR1A RELA SERTAD1 SIRT1 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53	12 interactors: APP CREBBP ELK1 EP300 HDAC1 HDAC5 KAT5 KLF6 SETD7 SP1 TP53 VHL
Entrez ID		80854	9314
HPRD ID		16226	03769
Ensembl ID		ENSG00000145391	ENSG00000136826
Uniprot IDs		Q8WTS6	O43474
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4JDS 4JLG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Chromatin Silencing At RDNA Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Silencing Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process DNA Methylation Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Cellular Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Receptor Signaling Pathway	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Organization Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Cellular Response To Hypoxia Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Chromosome Organization Chromatin Modification Response To Stress Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Rhythmic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Interaction With Symbiont Cellular Response To Organic Substance N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma lna locked maldi multiforme nanog nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma lna locked maldi multiforme nanog nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?