RIOK1 and G3BP2

Number of citations of the paper that reports this interaction (PubMedID 35589951)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RIOK1	G3BP2
Description		RIO kinase 1	G3BP stress granule assembly factor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing	Immune System Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs		Fostamatinib
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Shigella-associated diarrhea ( 33649051)	HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)
Interacting Genes		7 interacting genes: APP FBXO6 G3BP2 KDM1A SETD7 UBC YWHAB	68 interacting genes: ANXA1 CEBPA DANCR MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA OGT PDE4B PIN1 PRMT5 RIOK1 TRIM25 USP10 ZNF618
Entrez ID		83732	9908
HPRD ID		17978	06570
Ensembl ID		ENSG00000124784	ENSG00000138757
Uniprot IDs		Q9BRS2	A0A7I2V3P9 A0A7I2V647 Q9UN86
PDB IDs		4OTP 6G5I 6V0N 6ZV6 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7BOC	5DRV
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Cellular Response To CAMP Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Response To CAMP Protein Modification Process Phosphoserine Residue Binding Response To Fungicide	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Negative Regulation Of Cytokine Production Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Cell Motility Regulation Of Macromolecule Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of MRNA Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Developmental Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Extracellular Space
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