RIOK1

Description		RIO kinase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Fostamatinib
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Shigella-associated diarrhea ( 33649051)
Interacting Genes		7 interacting genes: APP FBXO6 G3BP2 KDM1A SETD7 UBC YWHAB
Entrez ID		83732
HPRD ID		17978
Ensembl ID		ENSG00000124784
Uniprot IDs		Q9BRS2
PDB IDs		4OTP 6G5I 6V0N 6ZV6 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7BOC
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Cellular Response To CAMP Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Regulation Of Cellular Response To Stress Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Response To CAMP Protein Modification Process Phosphoserine Residue Binding Response To Fungicide
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