SETD7 and STEAP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SETD7	STEAP3
Gene Name		SET domain containing (lysine methyltransferase) 7	STEAP family member 3, metalloreductase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Multivesicular Body Plasma Membrane Endosome Membrane Integral Component Of Membrane
	Molecular Function	P53 Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Ferric-chelate Reductase Activity Protein Binding Cupric Reductase Activity Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromatin Modification Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Heterochromatin Organization	Cellular Iron Ion Homeostasis Apoptotic Process Cell Cycle Protein Secretion Copper Ion Import Transferrin Transport Transmembrane Transport Oxidation-reduction Process Ferric Iron Import Into Cell Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Exosomal Secretion
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Iron uptake and transport Transferrin endocytosis and recycling
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: A1BG DNMT1 E2F1 ESR1 H3F3A HCFC1 HIST1H3A HIST1H4A HIST2H3C HIST3H3 KLF4 L3MBTL1 NR2F2 PPP1R12A PRKAR1A RELA SERTAD1 SIRT1 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53	5 interactors: BAD BNIP3L PKMYT1 SETD7 TPT1
Entrez ID		80854	55240
HPRD ID		16226	10285
Ensembl ID		ENSG00000145391	ENSG00000115107
Uniprot IDs		Q8WTS6	B8ZZX6 Q658P3
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4JDS 4JLG	2VNS 2VQ3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Chromatin Silencing At RDNA Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Silencing Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process DNA Methylation Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Cellular Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Receptor Signaling Pathway	Response To Virus Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Cellular Response To Chromate Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mitochondrial Protein Catabolic Process Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Glucokinase Activity Peptidyl-lysine Monomethylation Response To Chromate Organelle Organization Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Nicotine Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Regulation Of Apoptotic Process Response To Oleic Acid Pore Complex Assembly Modulation By Virus Of Host Process Peptidyl-lysine Dimethylation Type B Pancreatic Cell Proliferation Regulation Of Cell Death ADP Metabolic Process Mitochondrion Organization Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Virus Positive Regulation Of B Cell Differentiation Heterochromatin Organization Response To External Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Modulation By Virus Of Host Morphology Or Physiology Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Killing Of Cells Of Other Organism
Tagcloud ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes
Tagcloud (Difference) ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes
Tagcloud (Intersection) ?