SETD7 and L3MBTL1

Number of citations of the paper that reports this interaction (PMID 18408754)
50

Data Source:
BioGRID (pull down)

		SETD7	L3MBTL1
Gene Name		SET domain containing (lysine methyltransferase) 7	l(3)mbt-like 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	P53 Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Nucleosome Binding Nucleosomal Histone Binding SAM Domain Binding Methylated Histone Binding Histone Binding Identical Protein Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Chromatin Modification Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Histone Lysine Methylation Heterochromatin Organization	Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Chromatin Modification Hemopoiesis Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: A1BG DNMT1 E2F1 ESR1 H3F3A HCFC1 HIST1H3A HIST1H4A HIST2H3C HIST3H3 KLF4 L3MBTL1 NR2F2 PPP1R12A PRKAR1A RELA SERTAD1 SIRT1 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53	7 interactors: CBX3 ETV6 ETV7 HIST1H1B HIST4H4 RB1 SETD7
Entrez ID		80854	26013
HPRD ID		16226	16387
Ensembl ID		ENSG00000145391	ENSG00000185513
Uniprot IDs		Q8WTS6	Q9Y468
PDB IDs		1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4JDS 4JLG	1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Chromatin Silencing At RDNA Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Chromosome Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Silencing Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process DNA Methylation Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA Modification RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Cellular Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intracellular Receptor Signaling Pathway	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Modification Chromatin Remodeling Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Localization To Chromosome Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleosome Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Assembly Organelle Organization Nucleosome Organization RNA Metabolic Process Chromatin Assembly Or Disassembly Regulation Of Centromere Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Regulation Of Transcription From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Myeloid Cell Differentiation DNA Packaging Cellular Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Attachment Of Mitotic Spindle Microtubules To Kinetochore Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Establishment Of Protein Localization To Chromatin
Tagcloud ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modify modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Difference) ?		adenosylmethionine biotinylated broad chemoproteomics coactivator cofactor competition competitive confluent derivative druggable enantiomer exhibits groove hippo kit lysine mcf7 methyltransferase methyltransferases occupying pfi phenocopied pretreated unusual validate valuable yap yes	advances alterations asxl1 discovery driving epigenetic existence idh1 idh2 jak leukemic modifiers modify modifying mpn mpns myeloproliferative neoplasms nevertheless predate predominant prmt5 reading reviews stat suspected technologies tet2 translational
Tagcloud (Intersection) ?