YPEL3 and POLD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YPEL3	POLD1
Description		yippee like 3	DNA polymerase delta 1, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	Metal Ion Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Nuclease Activity Exonuclease Activity Protein Binding Zinc Ion Binding 3'-5'-DNA Exonuclease Activity 3'-5' Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity Enzyme Binding DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Positive Regulation Of Cellular Senescence	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process
Pathways			Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 25056061 28991256 29483656)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		122 interacting genes: ACTMAP AIRIM APP ARMC7 ATG9A ATXN1L BCAS2 C10orf55 CABP2 CDCA4 CDKN2D COL8A1 CRYBA1 CRYBA2 CYB5R2 CYSRT1 DMRT3 DOK6 DOK7 EID2B FAM168B FANCL FGF21 FHL2 FHL3 FHL5 FNDC3B FRS3 GCA GCM2 GEM GUCD1 HDAC7 HEXIM2 HGS HNRNPH1 HOXA1 HR HSD3B7 HSPB2 HSPB2-C11orf52 INTS11 KLHL38 KRTAP13-2 KRTAP15-1 KRTAP23-1 KRTAP3-1 KRTAP3-3 KRTAP6-2 LARP4 LIMS3 LIMS4 LMO2 LONRF1 MAD2L2 MDFI MKRN3 MORN3 MYOZ1 MYOZ3 NRF1 NUFIP2 ODAM OSTF1 OTX1 PIK3R3 PITX1 PLSCR4 POLD1 POLR1C POU2AF1 PPP2CA PRKAA2 PRKAB2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QRICH1 RBPMS RFC5 SH2D4A SHC3 SMUG1 SPAG8 SPG21 SPRYD7 SRPK2 STK16 TASOR2 TBX6 TENT5A TENT5B TEPSIN TGM7 TLE5 TLX3 TOX2 TP53INP1 TRAPPC2L TRAPPC6A TRIM10 TRIM55 TRIM63 TRIM73 TRIP6 TSC1 TSSK3 UBASH3A UBTD2 VENTX VGLL3 VWC2L WWOX ZIC1 ZNF441 ZNF76 ZNF765 ZYX	21 interacting genes: ADAMTSL4 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3
Entrez ID		83719	5424
HPRD ID		15683	08882
Ensembl ID		ENSG00000090238	ENSG00000062822
Uniprot IDs		P61236	A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0
PDB IDs			6S1M 6S1N 6S1O 6TNY 6TNZ 9EKB
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	DNA Replication DNA Repair DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair DNA Metabolic Process DNA-templated DNA Replication DNA Damage Response DNA Strand Elongation Involved In DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Delta DNA Polymerase Complex DNA Strand Elongation Telomere Maintenance Telomere Organization Mitotic Cell Cycle Phase Transition Cyclin D3-CDK4 Complex Cellular Response To Stress Cell Cycle Phase Transition Nucleic Acid Metabolic Process Chromosome, Telomeric Region DNA-directed DNA Polymerase Activity G1/S Transition Of Mitotic Cell Cycle Translesion Synthesis Cell Cycle G1/S Phase Transition Cyclin E1-CDK2 Complex DNA Synthesis Involved In UV-damage Excision Repair Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Leading Strand Elongation Zeta DNA Polymerase Complex Nucleobase-containing Compound Biosynthetic Process Postreplication Repair Regulation Of DNA Replication Nucleoplasm Nucleobase-containing Compound Metabolic Process MutLalpha Complex Binding Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA-templated DNA Replication Initiation Double-strand Break Repair Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process
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