YPEL3 and HEXIM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YPEL3	HEXIM2
Description		yippee like 3	HEXIM P-TEFb complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Metal Ion Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 25056061 28991256 29483656)	Asthma ( 31619474 31959851) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		122 interacting genes: ACTMAP AIRIM APP ARMC7 ATG9A ATXN1L BCAS2 C10orf55 CABP2 CDCA4 CDKN2D COL8A1 CRYBA1 CRYBA2 CYB5R2 CYSRT1 DMRT3 DOK6 DOK7 EID2B FAM168B FANCL FGF21 FHL2 FHL3 FHL5 FNDC3B FRS3 GCA GCM2 GEM GUCD1 HDAC7 HEXIM2 HGS HNRNPH1 HOXA1 HR HSD3B7 HSPB2 HSPB2-C11orf52 INTS11 KLHL38 KRTAP13-2 KRTAP15-1 KRTAP23-1 KRTAP3-1 KRTAP3-3 KRTAP6-2 LARP4 LIMS3 LIMS4 LMO2 LONRF1 MAD2L2 MDFI MKRN3 MORN3 MYOZ1 MYOZ3 NRF1 NUFIP2 ODAM OSTF1 OTX1 PIK3R3 PITX1 PLSCR4 POLD1 POLR1C POU2AF1 PPP2CA PRKAA2 PRKAB2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QRICH1 RBPMS RFC5 SH2D4A SHC3 SMUG1 SPAG8 SPG21 SPRYD7 SRPK2 STK16 TASOR2 TBX6 TENT5A TENT5B TEPSIN TGM7 TLE5 TLX3 TOX2 TP53INP1 TRAPPC2L TRAPPC6A TRIM10 TRIM55 TRIM63 TRIM73 TRIP6 TSC1 TSSK3 UBASH3A UBTD2 VENTX VGLL3 VWC2L WWOX ZIC1 ZNF441 ZNF76 ZNF765 ZYX	47 interacting genes: ADAMTSL4 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B DRC4 EGFL7 FAM161A GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789
Entrez ID		83719	124790
HPRD ID		15683	08129
Ensembl ID		ENSG00000090238	ENSG00000168517
Uniprot IDs		P61236	Q96MH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus	Negative Regulation Of Lens Fiber Cell Differentiation 7SK SnRNA Binding Regulation Of Lens Fiber Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process P-TEFb Complex SnRNA Binding Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Shelterin Complex Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Telomerase Activity Bud Elongation Involved In Lung Branching Protein Binding Nucleus Cyclin/CDK Positive Transcription Elongation Factor Complex Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Epithelial To Mesenchymal Transition Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding Negative Regulation Of Epithelial To Mesenchymal Transition DNA Binding Regulation Of Cellular Response To Growth Factor Stimulus G-rich Strand Telomeric DNA Binding Negative Regulation Of Epithelial Cell Differentiation Telomeric Loop Disassembly Regulation Of Neurotrophin TRK Receptor Signaling Pathway Telomere Capping Regulation Of Cell Cycle Branch Elongation Of An Epithelium DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Viral Transcription Protein Serine/threonine Kinase Activator Activity Host-mediated Activation Of Viral Transcription Axis Elongation Regulation Of Receptor Internalization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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