RAD51B

Description		RAD51 paralog B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Blastocyst Growth DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Somite Development
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Asthma ( 32296059 30929738 31361310 31619474 31959851 34103634 27182965) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Brain asymmetrical skew (vertical) ( 33836062) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Nose size ( 27182965) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes ( 34127860) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 32888494 27863252)
Novel Interacting Genes		1 novel interacting genes: FADS2
Interacting Genes		11 interacting genes: ABL1 FAM9B H1-0 H2BC8 H3C1 H4C14 MEOX2 RAD51C RAD51D RPAIN SWSAP1
Entrez ID		5890
HPRD ID		04255
Ensembl ID		ENSG00000182185
Uniprot IDs		C9JYJ0 O15315
PDB IDs		8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Chromosome Organization Four-way Junction DNA Binding Protein-DNA Complex Assembly Structural Constituent Of Chromatin Nucleosome Assembly DNA Binding Nucleosome Nucleosome Organization Telomere Organization Rad51B-Rad51C-Rad51D-XRCC2 Complex Chromosome Telomere Maintenance Via Recombination ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Protein-containing Complex Assembly Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Protein-containing Complex Organization Replication Fork Reciprocal Meiotic Recombination Nucleoplasm DNA Repair Homologous Recombination Double-strand Break Repair DNA Recombination Negative Regulation Of DNA Recombination Regulation Of Cell Migration Involved In Sprouting Angiogenesis Protein Localization To Cytoplasmic Microtubule Plus-end Female Meiosis Sister Chromatid Cohesion Chromatin Remodeling Transitional One Stage B Cell Differentiation DNA Metabolic Process Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Rad51C-XRCC3 Complex Meiotic DNA Recombinase Assembly Positive Regulation Of Cellular Response To Oxidative Stress Acyl-CoA 6-desaturase Activity Acyl-CoA Desaturase Activity Shu Complex Protein Heterodimerization Activity DNA Damage Response Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Chromatin Organization Positive Regulation Of Response To Oxidative Stress Stearoyl-CoA 9-desaturase Activity Telomere Maintenance
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