TMUB1 and TAP2

Number of citations of the paper that reports this interaction (PubMedID 35961308)
0

Data Source:
BioGRID (unspecified method)

		TMUB1	TAP2
Description		transmembrane and ubiquitin like domain containing 1	transporter 2, ATP binding cassette subfamily B member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Centrosome Cytoskeleton Plasma Membrane Membrane Synapse Postsynaptic Membrane Recycling Endosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Speck Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity MHC Class Ib Protein Binding MHC Protein Binding Peptide Antigen Binding Metal Ion Binding TAP1 Binding Tapasin Binding ABC-type Transporter Activity Peptide Transmembrane Transporter Activity
	Biological Process	ERAD Pathway	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Protein Transport Peptide Transport Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Peptide Antigen Transport Transmembrane Transport
Pathways			ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type1
GWAS		Eyebrow thickness ( 26926045)	Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Nephropathy ( 21399633) Platelet distribution width ( 32888494) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		13 interacting genes: APP CD274 CYP51A1 GOLM1 HMGCR NPLOC4 SGTB TAP2 TMBIM6 TMEM14B TRA UFD1 VCP	10 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP TMUB1
Entrez ID		83590	6891
HPRD ID		12910	01360
Ensembl ID		ENSG00000164897	ENSG00000204267
Uniprot IDs		A0A090N8Q3 Q9BVT8	Q03519 Q5JNW1 Q9UP03 X5CMH5
PDB IDs			5U1D 8T46 8T4E 8T4F 8T4G 8T4H 8T4I 8T4J
Enriched GO Terms of Interacting Partners?		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol Regulation Of Amyloid-beta Clearance UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Protein Localization Response To Endoplasmic Reticulum Stress Negative Regulation Of Amyloid-beta Clearance Cellular Response To Misfolded Protein Endoplasmic Reticulum ERAD Pathway Response To Misfolded Protein T Cell Mediated Cytotoxicity Regulation Of RIG-I Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cholesterol Biosynthetic Process T Cell Mediated Immunity Positive Regulation Of ATP Metabolic Process Polyubiquitin Modification-dependent Protein Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Localization Sterol Biosynthetic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Endoplasmic Reticulum Membrane Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Negative Regulation Of Immune System Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Flavin Adenine Dinucleotide Catabolic Process Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Visual Behavior Negative Regulation Of Gene Expression	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Peptide Antigen Phagocytic Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane TAP2 Binding TAP1 Binding MHC Class I Peptide Loading Complex MHC Class I Protein Complex Threonine-type Endopeptidase Activity Peptide Antigen Assembly With MHC Class I Protein Complex Proteasome Core Complex, Beta-subunit Complex Protein-containing Complex Assembly Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Proteasome Assembly Protein Trimerization Protein-containing Complex Organization MHC Class I Protein Binding Proteasome Core Complex Early Endosome Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Immune System Process Regulation Of T Cell Mediated Cytotoxicity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway ER To Golgi Transport Vesicle Membrane Regulation Of Natural Killer Cell Mediated Immunity Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Proteasome Complex MHC Class Ib Protein Complex Assembly Peptide Antigen Stabilization Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity External Side Of Plasma Membrane Cellular Component Assembly Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Acetylcholine Receptor Activator Activity Lipoprotein Particle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?