TMUB1 and CD274

Number of citations of the paper that reports this interaction (PubMedID 36376293)
55

Data Source:
BioGRID (pull down, pull down)

		TMUB1	CD274
Description		transmembrane and ubiquitin like domain containing 1	CD274 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Centrosome Cytoskeleton Plasma Membrane Membrane Synapse Postsynaptic Membrane Recycling Endosome	Extracellular Region Nucleus Nucleoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Receptor Ligand Activity
	Biological Process	ERAD Pathway	Adaptive Immune Response Immune System Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Response To Cytokine TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Activated T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Activation Regulation Of T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways			Co-inhibition by PD-1 STAT3 nuclear events downstream of ALK signaling Regulation of PD-L1(CD274) translation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs			Sildenafil Valproic acid Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Camrelizumab Envafolimab Cosibelimab AUNP-12 CA-170 anti-OX40 antibody BMS 986178
Diseases
GWAS		Eyebrow thickness ( 26926045)	Blood protein levels ( 30072576)
Interacting Genes		13 interacting genes: APP CD274 CYP51A1 GOLM1 HMGCR NPLOC4 SGTB TAP2 TMBIM6 TMEM14B TRA UFD1 VCP	14 interacting genes: ANXA1 CD80 COPS5 CSNK2A1 DCAF1 HMGA1 HUWE1 ITGB1 OTUB1 PDCD1 TMUB1 UBQLN4 USP5 USP8
Entrez ID		83590	29126
HPRD ID		12910	05655
Ensembl ID		ENSG00000164897	ENSG00000120217
Uniprot IDs		A0A090N8Q3 Q9BVT8	Q0GN75 Q9NZQ7
PDB IDs			3BIK 3BIS 3FN3 3SBW 4Z18 4ZQK 5C3T 5GGT 5GRJ 5IUS 5J89 5J8O 5JDR 5JDS 5N2D 5N2F 5NIU 5O45 5O4Y 5X8L 5X8M 5XJ4 5XXY 6L8R 6NM7 6NM8 6NNV 6NOJ 6NOS 6NP9 6PV9 6R3K 6RPG 6VQN 6YCR 7BEA 7C88 7CZD 7DCV 7DY7 7NLD 7OUN 7SJQ 7TPS 7UX5 7UXO 7UXP 7UXQ 7VUN 7XAD 7XAE 7XYQ 7YDS 8ALX 8AOK 8AOM 8JBA 8K5N 8OR1 8P1O 8R6Q 8RPB 8XR5 9INU
Enriched GO Terms of Interacting Partners?		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol Regulation Of Amyloid-beta Clearance UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Protein Localization Response To Endoplasmic Reticulum Stress Negative Regulation Of Amyloid-beta Clearance Cellular Response To Misfolded Protein Endoplasmic Reticulum ERAD Pathway Response To Misfolded Protein T Cell Mediated Cytotoxicity Regulation Of RIG-I Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cholesterol Biosynthetic Process T Cell Mediated Immunity Positive Regulation Of ATP Metabolic Process Polyubiquitin Modification-dependent Protein Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Localization Sterol Biosynthetic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Endoplasmic Reticulum Membrane Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Negative Regulation Of Immune System Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Flavin Adenine Dinucleotide Catabolic Process Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Visual Behavior Negative Regulation Of Gene Expression	Protein Metabolic Process Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Double-strand Break Repair Protein Modification By Small Protein Removal Protein K48-linked Deubiquitination Proteolysis Negative Regulation Of DNA Repair Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Leukocyte Cell-cell Adhesion DeNEDDylase Activity Negative Regulation Of Lymphocyte Activation Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Leukocyte Activation DNA Metabolic Process Protein Modification Process Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Cell Activation Regulation Of Adaptive Immune Response Negative Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Negative Regulation Of Immune Response To Tumor Cell Cysteine-type Deubiquitinase Activity DNA Repair Negative Regulation Of Apoptotic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Deubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Mediated Immunity Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Adhesion Regulation Of Metabolic Process Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Metabolic Process Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of T-helper Cell Differentiation Proteolysis Involved In Protein Catabolic Process
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