TMUB1 and HMGCR

Number of citations of the paper that reports this interaction (PubMedID 35961308)
0

Data Source:
BioGRID (unspecified method)

		TMUB1	HMGCR
Description		transmembrane and ubiquitin like domain containing 1	3-hydroxy-3-methylglutaryl-CoA reductase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endosome Centrosome Cytoskeleton Plasma Membrane Membrane Synapse Postsynaptic Membrane Recycling Endosome	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor GTPase Regulator Activity NADP Binding NADPH Binding Coenzyme A Binding
	Biological Process	ERAD Pathway	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Visual Learning Coenzyme A Metabolic Process Sterol Biosynthetic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Long-term Synaptic Potentiation Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Amyloid-beta Clearance
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Eyebrow thickness ( 26926045)	Apolipoprotein B levels ( 32203549) Body mass index ( 20935630) Cholesterol ( 31902109) Cholesterol, total ( 19060911 28270201 20686565 26582766 25961943 24097068) Coronary artery disease ( 33020668) LDL cholesterol ( 18802019 26582766 25961943 24097068 18193044 20864672 20686565 19060906 19060911) LDL cholesterol levels ( 32203549 28334899 31087446) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 29403010 32154731 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Quantitative traits ( 19197348) Total cholesterol levels ( 31087446 30275531 28334899 33339817) Type 2 diabetes ( 32499647)
Interacting Genes		13 interacting genes: APP CD274 CYP51A1 GOLM1 HMGCR NPLOC4 SGTB TAP2 TMBIM6 TMEM14B TRA UFD1 VCP	5 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13 TMUB1
Entrez ID		83590	3156
HPRD ID		12910	00836
Ensembl ID		ENSG00000164897	ENSG00000113161
Uniprot IDs		A0A090N8Q3 Q9BVT8	P04035
PDB IDs			1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB 8PKN 8S6B
Enriched GO Terms of Interacting Partners?		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol Regulation Of Amyloid-beta Clearance UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of Protein Localization Response To Endoplasmic Reticulum Stress Negative Regulation Of Amyloid-beta Clearance Cellular Response To Misfolded Protein Endoplasmic Reticulum ERAD Pathway Response To Misfolded Protein T Cell Mediated Cytotoxicity Regulation Of RIG-I Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cholesterol Biosynthetic Process T Cell Mediated Immunity Positive Regulation Of ATP Metabolic Process Polyubiquitin Modification-dependent Protein Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Cellular Localization Sterol Biosynthetic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Endoplasmic Reticulum Membrane Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Negative Regulation Of Immune System Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Flavin Adenine Dinucleotide Catabolic Process Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Visual Behavior Negative Regulation Of Gene Expression	Regulation Of Intracellular Transport Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Metabolic Process Negative Regulation Of Intracellular Transport Regulation Of Steroid Biosynthetic Process Regulation Of Cellular Localization Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Positive Regulation Of Lipid Biosynthetic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Regulation Of Cargo Loading Into COPII-coated Vesicle Endothelial Tube Lumen Extension Positive Regulation Of Lipid Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Negative Regulation Of Endocytic Recycling Positive Regulation Of Small Molecule Metabolic Process SREBP-SCAP-Insig Complex Cellular Response To Peptide Hormone Stimulus Regulation Of Lipid Biosynthetic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Negative Regulation Of SREBP Signaling Pathway Sorting Endosome CAMP-dependent Protein Kinase Activity Transferrin Transport Regulation Of Small GTPase Mediated Signal Transduction Intracellular Transport GTPase Activator Activity Protein Transport Regulation Of Lipid Metabolic Process Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Cranial Suture Morphogenesis Response To Sterol Depletion Negative Regulation Of Protein Exit From Endoplasmic Reticulum Nuclear Transport Nucleocytoplasmic Transport Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Small Molecule Metabolic Process SREBP Signaling Pathway Negative Regulation Of Cholesterol Metabolic Process Response To Peptide Hormone Cellular Response To Sterol Depletion CAMP-dependent Protein Kinase Complex
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