NUF2 and FCRLA

		NUF2	FCRLA
Description		NUF2 component of NDC80 kinetochore complex	Fc receptor like A
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane Ndc80 Complex	Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Protein Binding Microtubule Binding Protein-containing Complex Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization	Immune Response Cell Surface Receptor Signaling Pathway Cell Differentiation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 29273806) Bipolar disorder ( 34002096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)	Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		11 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 OGT SDCBP2
Entrez ID		83540	84824
HPRD ID		10817	06058
Ensembl ID		ENSG00000143228	ENSG00000132185
Uniprot IDs		Q9BZD4	Q7L513
PDB IDs		2VE7 3IZ0 8G0P	4HWN
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Organization Membraneless Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Kinetochore Kinetochore Organization Organelle Assembly Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Midzone Attachment Of Spindle Microtubules To Kinetochore Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis I Chromosome, Centromeric Region Kinetochore Binding Chromosome Passenger Complex Midbody Cell Cycle G2/M Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Mitotic Spindle Midzone Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Spindle Assembly Involved In Female Meiosis Kinetochore Assembly Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly Regulation Of Sister Chromatid Segregation Condensed Chromosome, Centromeric Region Positive Regulation Of Cell Cycle Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Meiotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Segregation Regulation Of Nuclear Division Protein Serine/threonine/tyrosine Kinase Activity Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Organelle Localization Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Spindle Microtubule Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle	Meiotic Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Ndc80 Complex Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Kinetochore Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitochondrial Outer Membrane Translocase Complex Porin Activity Pore Complex Protein Import Into Mitochondrial Matrix Protein Transmembrane Transporter Activity Positive Regulation Of Natural Killer Cell Mediated Immunity Negative Regulation Of Mitotic Nuclear Division Protein Localization To Mitochondrion
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