CHST9 and MIB1

Data Source: HiPPIP (Novel)

		CHST9	MIB1
Name		carbohydrate sulfotransferase 9	MIB E3 ubiquitin protein ligase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse
	Molecular Function	Dermatan 4-sulfotransferase Activity Sulfotransferase Activity Transferase Activity Chondroitin 4-sulfotransferase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Sulfur Compound Metabolic Process Carbohydrate Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Hormone Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways		None	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
GWAS		Blood protein levels ( 30072576 ) Breast cancer ( 23535729 29059683 ) Bronchopulmonary dysplasia ( 23897914 ) Dental caries ( 23259602 ) Metabolite levels ( 23823483 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 )	Brain morphology (MOSTest) ( 32665545 ) Mean spheric corpuscular volume ( 32888494 ) Myocardial infarction ( 33532862 ) Severe progression in rheumatoid arthritis ( 29065906 )
Novel Interactors		1 novel interactors: MIB1	3 novel interactors: CABLES1 CHST9 RMC1
Interacting Genes		1 interacting genes: LHCGR	17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN
Entrez ID		83539	57534
HPRD ID		13058	06660
Ensembl ID		ENSG00000154080	ENSG00000101752
Uniprot IDs		Q7L1S5	Q86YT6
PDB IDs		Not available	4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
GO Terms Enriched among Interactors		Centriolar Satellite Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Development Of Secondary Sexual Characteristics Response To Luteinizing Hormone Neural Tube Formation Protein-hormone Receptor Activity Positive Regulation Of Inositol Phosphate Biosynthetic Process Male Genitalia Development Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Hormone Biosynthetic Process Seminiferous Tubule Development Reproductive System Development Cellular Response To Gonadotropin Stimulus Uterus Development Female Gonad Development Embryonic Epithelial Tube Formation Response To Gonadotropin Genitalia Development Regulation Of Hormone Metabolic Process G Protein-coupled Peptide Receptor Activity Epithelial Tube Formation Ovulation Cycle Process Ovarian Follicle Development Somitogenesis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Segmentation Animal Organ Development Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Regulation Of Steroid Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination