MIB1 and CHST9

		MIB1	CHST9
Description		MIB E3 ubiquitin protein ligase 1	carbohydrate sulfotransferase 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse	Golgi Membrane Extracellular Region Golgi Apparatus Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Dermatan 4-sulfotransferase Activity Sulfotransferase Activity Transferase Activity Chondroitin 4-sulfotransferase Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Sulfur Compound Metabolic Process Carbohydrate Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Hormone Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)	Blood protein levels ( 30072576) Breast cancer ( 23535729 29059683) Bronchopulmonary dysplasia ( 23897914) Dental caries ( 23259602) Metabolite levels ( 23823483) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN	1 interacting genes: LHCGR
Entrez ID		57534	83539
HPRD ID		06660	13058
Ensembl ID		ENSG00000101752	ENSG00000154080
Uniprot IDs		Q86YT6	Q7L1S5
PDB IDs		4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination	Centriolar Satellite Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Development Of Secondary Sexual Characteristics Response To Luteinizing Hormone Neural Tube Formation Protein-hormone Receptor Activity Positive Regulation Of Inositol Phosphate Biosynthetic Process Male Genitalia Development Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Hormone Biosynthetic Process Seminiferous Tubule Development Reproductive System Development Cellular Response To Gonadotropin Stimulus Uterus Development Female Gonad Development Embryonic Epithelial Tube Formation Response To Gonadotropin Genitalia Development Regulation Of Hormone Metabolic Process G Protein-coupled Peptide Receptor Activity Epithelial Tube Formation Ovulation Cycle Process Ovarian Follicle Development Somitogenesis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Segmentation Animal Organ Development Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Regulation Of Steroid Biosynthetic Process
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