FGF2 and RPL6

Number of citations of the paper that reports this interaction (PubMedID 9826564)
0

Data Source:
HPRD (two hybrid, in vitro)

		FGF2	RPL6
Description		fibroblast growth factor 2	ribosomal protein L6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Ribonucleoprotein Granule Synapse Ribonucleoprotein Complex
	Molecular Function	Fibroblast Growth Factor Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Chemokine Binding Chemoattractant Activity Identical Protein Binding Histone H3K9me2/3 Reader Activity Receptor-receptor Interaction	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Angiogenesis Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Organ Induction Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Chromatin Organization Transcription By RNA Polymerase II Chemotaxis Signal Transduction Ras Protein Signal Transduction Nervous System Development Neuroblast Proliferation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Animal Organ Morphogenesis Glial Cell Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Substantia Nigra Development Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Neurogenesis Cell Differentiation Hyaluronan Catabolic Process Lung Development Regulation Of Cell Migration Paracrine Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Response To Ethanol Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Retinal Cell Programmed Cell Death Behavioral Response To Ethanol Embryonic Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Stem Cell Differentiation Stem Cell Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Neuroepithelial Cell Differentiation Chondroblast Differentiation Mammary Gland Epithelial Cell Differentiation Angiogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Wound Healing ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Stem Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Response To Wortmannin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Lymphatic Endothelial Cell Migration Positive Regulation Of Epithelial Tube Formation Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis	Cytoplasmic Translation Regulation Of DNA-templated Transcription Translation
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Formation of intermediate mesoderm Formation of the nephric duct TGFBR3 regulates FGF2 signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Sucralfate Pentosan polysulfate Heparin 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid ABT-510
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 30542056) Body mass index ( 25673413) Irritable bowel syndrome ( 24797007) Mosquito bite size ( 28199695) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Blond vs. brown/black hair color ( 30531825) Blood pressure ( 21572416) Body mass index ( 26426971) Coffee consumption ( 29367735) Diastolic blood pressure ( 26390057) Esophageal cancer ( 21642993) Hip circumference adjusted for BMI ( 34021172) Systolic blood pressure ( 26390057)
Interacting Genes		30 interacting genes: API5 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 GPC3 GPC4 HSPG2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 SNTG1 THBS1 VTN	18 interacting genes: CSNK2A1 DUX4 EIF6 FBXO7 FGF2 FOXP1 H2AC4 IL7R IVNS1ABP LINC01554 MAP3K14 MT-ND1 NFKB2 NPAS2 OGT RPL29 SEL1L STAU1
Entrez ID		2247	6128
HPRD ID		00622	04745
Ensembl ID		ENSG00000138685	ENSG00000089009
Uniprot IDs		D9ZGF5 P09038	Q02878 Q8TBK5
PDB IDs		1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 5X1O 6L4O 8HU7 8HUE 8OM6	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9FPZ 9FQ0 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Binding Cell Surface Receptor Signaling Pathway Heparin Binding Golgi Lumen Fibroblast Growth Factor Receptor Activity Cell Migration Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Motility Extracellular Region Protein Kinase CK2 Complex Cell Surface Lysosomal Lumen Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Identical Protein Binding Negative Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Collagen V Binding Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Proliferation Symbiont-mediated Disruption Of Host Cell PML Body Developmental Process Wnt Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Extracellular Matrix Regulation Of Cell Communication Regulation Of Growth PcG Protein Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Cell Communication	Sin3-type Complex Rhythmic Process Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Nucleoplasm Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Translation Negative Regulation Of Translational Initiation Response To Stress Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hsp90 Protein Binding Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Apoptotic Process Regulation Of Hemopoiesis Hemopoiesis Assembly Of Large Subunit Precursor Of Preribosome Non-canonical NF-kappaB Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Response To Mechanical Stimulus Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Development Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Cell Development Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Leukocyte Apoptotic Process Interleukin-7 Receptor Activity Regulation Of Glycolytic Process Bcl3/NF-kappaB2 Complex
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