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FGF2 and GPC4
Number of citations of the paper that reports this interaction (PubMedID
11066092
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
FGF2
GPC4
Description
fibroblast growth factor 2
glypican 4
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Extracellular Region
Nucleus
Golgi Lumen
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Lysosomal Lumen
Synapse
Extracellular Exosome
Side Of Membrane
Glutamatergic Synapse
Molecular Function
Fibroblast Growth Factor Receptor Binding
Cytokine Activity
Integrin Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemokine Binding
Chemoattractant Activity
Identical Protein Binding
Histone H3K9me2/3 Reader Activity
Receptor-receptor Interaction
Protein Binding
Coreceptor Activity
Biological Process
Angiogenesis
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Organ Induction
Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Neuroblast Proliferation
Chromatin Organization
Transcription By RNA Polymerase II
Chemotaxis
Signal Transduction
Ras Protein Signal Transduction
Nervous System Development
Neuroblast Proliferation
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Embryo Development Ending In Birth Or Egg Hatching
Animal Organ Morphogenesis
Glial Cell Differentiation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Fibroblast Migration
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Substantia Nigra Development
Cerebellar Granule Cell Precursor Proliferation
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Neurogenesis
Cell Differentiation
Hyaluronan Catabolic Process
Lung Development
Regulation Of Cell Migration
Paracrine Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Cell Fate Specification
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Migration
Response To Ethanol
Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Retinal Cell Programmed Cell Death
Behavioral Response To Ethanol
Embryonic Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Axon Injury
Stem Cell Differentiation
Stem Cell Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Cell Cycle
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Corticotropin Hormone Secreting Cell Differentiation
Thyroid-stimulating Hormone-secreting Cell Differentiation
Neuroepithelial Cell Differentiation
Chondroblast Differentiation
Mammary Gland Epithelial Cell Differentiation
Angiogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of Wound Healing
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Mechanical Stimulus
Stem Cell Proliferation
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Lens Fiber Cell Differentiation
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Neuroepithelial Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Sprouting Angiogenesis
Response To Wortmannin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Lymphatic Endothelial Cell Migration
Positive Regulation Of Epithelial Tube Formation
Regulation Of Morphogenesis Of An Epithelium
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Positive Regulation Of DNA Biosynthetic Process
Negative Regulation Of Stem Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Stem Cell Differentiation
Positive Regulation Of Endothelial Cell Chemotaxis
Regulation Of Signal Transduction
Wnt Signaling Pathway
Cell Migration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Synaptic Membrane Adhesion
Regulation Of Presynapse Assembly
Pathways
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Formation of intermediate mesoderm
Formation of the nephric duct
TGFBR3 regulates FGF2 signaling
Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Glycosaminoglycan-protein linkage region biosynthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Attachment and Entry
Attachment and Entry
Retinoid metabolism and transport
Respiratory syncytial virus (RSV) attachment and entry
RSV-host interactions
Drugs
Sucralfate
Pentosan polysulfate
Heparin
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
ABT-510
Diseases
GWAS
A body shape index (
34021172
)
Acne (severe) (
30542056
)
Body mass index (
25673413
)
Irritable bowel syndrome (
24797007
)
Mosquito bite size (
28199695
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Interacting Genes
30 interacting genes:
API5
CASP1
CD44
CEP57
CRYAB
CSNK2A1
CSNK2A2
CSNK2B
CXCL13
FGFBP1
FGFR1
FGFR3
FGFR4
FGFRL1
GPC3
GPC4
HSPG2
NRP1
PF4
PRMT1
PTX3
RPL6
RPS19
RPS6KA3
SDC1
SDC2
SDC3
SNTG1
THBS1
VTN
10 interacting genes:
ABHD17A
ACP5
AKAP9
CCNC
COL18A1
FGF2
PICK1
PTEN
PTPRD
PTPRF
Entrez ID
2247
2239
HPRD ID
00622
02160
Ensembl ID
ENSG00000138685
ENSG00000076716
Uniprot IDs
D9ZGF5
P09038
O75487
PDB IDs
1BAS
1BFB
1BFC
1BFF
1BFG
1BLA
1BLD
1CVS
1EV2
1FGA
1FQ9
1II4
1IIL
2BFH
2FGF
2M49
4FGF
4OEE
4OEF
4OEG
5X1O
6L4O
8HU7
8HUE
8OM6
Enriched GO Terms of Interacting Partners
?
Fibroblast Growth Factor Binding
Cell Surface Receptor Signaling Pathway
Heparin Binding
Golgi Lumen
Fibroblast Growth Factor Receptor Activity
Cell Migration
Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Motility
Extracellular Region
Protein Kinase CK2 Complex
Cell Surface
Lysosomal Lumen
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Identical Protein Binding
Negative Regulation Of Proteolysis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Endothelial Cell Migration
Regulation Of Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Cellular Response To Growth Factor Stimulus
Collagen V Binding
Positive Regulation Of Signal Transduction
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Proteolysis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Apoptotic Signaling Pathway
Regulation Of Endothelial Cell Proliferation
Symbiont-mediated Disruption Of Host Cell PML Body
Developmental Process
Wnt Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signaling
Extracellular Matrix
Regulation Of Cell Communication
Regulation Of Growth
PcG Protein Complex
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Phospholipase Activity
Positive Regulation Of MAPK Cascade
Cell Communication
Presynaptic Membrane Organization
Presynaptic Membrane Assembly
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Phosphoprotein Phosphatase Activity
Synaptic Membrane Adhesion
Regulation Of Response To Wounding
Dendritic Spine Organization
Identical Protein Binding
System Development
Nervous System Development
Neuron Projection Organization
Response To Electrical Stimulus
Postsynapse Organization
Negative Regulation Of Superoxide Anion Generation
Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation
Cell-cell Signaling
Cell Communication
Signaling
Membrane Organization
Postsynaptic Density
Negative Regulation Of Synaptic Vesicle Clustering
Membrane Assembly
Chondroitin Sulfate Proteoglycan Binding
Response To Stress
Response To Wortmannin
Positive Regulation Of Inner Ear Receptor Cell Differentiation
Negative Regulation Of Wound Healing
Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Cell Fate Specification
Positive Regulation Of Lens Fiber Cell Differentiation
Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Neuron Projection
Trans-synaptic Signaling
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Negative Regulation Of Keratinocyte Migration
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Synaptic Signaling
Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
Regulation Of Neurogenesis
Protein Dephosphorylation
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Angiogenesis Involved In Coronary Vascular Morphogenesis
Regulation Of Organ Growth
Regulation Of Retinal Cell Programmed Cell Death
Lymphatic Endothelial Cell Migration
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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