WNT2 and WNT3A

Number of citations of the paper that reports this interaction (PMID 10557084)
26

Data Source:
HPRD (in vitro)

		WNT2	WNT3A
Gene Name		wingless-type MMTV integration site family member 2	wingless-type MMTV integration site family, member 3A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Plasma Membrane Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Early Endosome Membrane
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Agonist Activity	Transcription Coactivator Activity Frizzled Binding Frizzled-2 Binding Protein Binding Protein Domain Specific Binding Receptor Agonist Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neuron Differentiation Lung Development Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Positive Regulation Of Cell Proliferation COP9 Signalosome Assembly Negative Regulation Of Neuron Projection Development Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Positive Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Palate Development Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling negative regulation of TCF-dependent signaling by WNT ligand antagonists Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		8 interactors: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	11 interactors: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		7472	89780
HPRD ID		00999	05897
Ensembl ID		ENSG00000105989	ENSG00000154342
Uniprot IDs		A4D0V1 P09544	P56704
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Wnt Signaling Pathway Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Osteoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Acid Chemical Regulation Of Catenin Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Axis Elongation Ossification Negative Regulation Of BMP Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuroblast Proliferation Organ Morphogenesis Cellular Response To Lipid Regulation Of BMP Signaling Pathway Somitogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Respiratory Burst After Phagocytosis Convergent Extension Involved In Somitogenesis Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Positive Regulation Of Mesodermal Cell Fate Specification Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Stem Cell Proliferation Negative Regulation Of Developmental Growth Cellular Response To Organonitrogen Compound Regulation Of Cell Morphogenesis Growth Somite Development Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Neural Precursor Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Cardiac Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment	Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Receptor Localization To Synapse Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell-cell Signaling Protein Localization To Synapse Anatomical Structure Morphogenesis Canonical Wnt Signaling Pathway Neuron Differentiation Signaling Tissue Morphogenesis Regulation Of Embryonic Development Cell Communication Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway System Development Regulation Of Signaling Nervous System Development Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Wnt Signaling Pathway Generation Of Neurons Receptor Clustering Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurogenesis Nucleotide Phosphorylation Organ Morphogenesis Branching Involved In Ureteric Bud Morphogenesis Hard Palate Development Signal Transduction Morphogenesis Of A Branching Epithelium Epithelium Development Ureteric Bud Morphogenesis Negative Regulation Of Signal Transduction Morphogenesis Of A Branching Structure Developmental Process Negative Regulation Of Signaling Nephron Morphogenesis Renal Tubule Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of BMP Signaling Pathway Stem Cell Proliferation Positive Regulation Of Signal Transduction Response To Stimulus Tube Development Cell Morphogenesis Involved In Differentiation Renal Tubule Development Cell Proliferation
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ikbkg ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf
Tagcloud (Intersection) ?