WNT2 and AQP5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WNT2	AQP5
Gene Name		wingless-type MMTV integration site family member 2	aquaporin 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Plasma Membrane Extracellular Matrix	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Microvillus Basal Plasma Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Agonist Activity	Protein Binding Water Channel Activity Glycerol Channel Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neuron Differentiation Lung Development Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	Water Transport Excretion Cellular Water Homeostasis Carbon Dioxide Transport Glycerol Transport Pancreatic Juice Secretion Ion Transmembrane Transport Odontogenesis Saliva Secretion Camera-type Eye Morphogenesis Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Passive transport by Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		8 interactors: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	7 interactors: GLRX HNRNPK KRT31 KRT40 MDFI NOTCH2NL WNT2
Entrez ID		7472	362
HPRD ID		00999	02706
Ensembl ID		ENSG00000105989
Uniprot IDs		A4D0V1 P09544	P55064
PDB IDs			3D9S
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Wnt Signaling Pathway Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Osteoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Acid Chemical Regulation Of Catenin Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Axis Elongation Ossification Negative Regulation Of BMP Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuroblast Proliferation Organ Morphogenesis Cellular Response To Lipid Regulation Of BMP Signaling Pathway Somitogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Respiratory Burst After Phagocytosis Convergent Extension Involved In Somitogenesis Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Positive Regulation Of Mesodermal Cell Fate Specification Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Stem Cell Proliferation Negative Regulation Of Developmental Growth Cellular Response To Organonitrogen Compound Regulation Of Cell Morphogenesis Growth Somite Development Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Neural Precursor Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Cardiac Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment	Protein Deglutathionylation Embryonic Placenta Development Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Placenta Development Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Iris Morphogenesis Atrial Cardiac Muscle Tissue Morphogenesis Lung Induction Regulation Of Wnt Signaling Pathway Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	accordingly aquaporin basis categorize curative ebc epidermal immunohistochemistry intensity marker mcf microarray multivariate overexpressed percentage pr progesterone prognostic prominent score scored staining stating strong sum surgery unfavorable univariate weak
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	accordingly aquaporin basis categorize curative ebc epidermal immunohistochemistry intensity marker mcf microarray multivariate overexpressed percentage pr progesterone prognostic prominent score scored staining stating strong sum surgery unfavorable univariate weak
Tagcloud (Intersection) ?