WNT2 and AQP5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		WNT2	AQP5
Name		Wnt family member 2	aquaporin 5
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix Wnt Signalosome	Endoplasmic Reticulum Plasma Membrane Microvillus Basal Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Wnt Signaling Pathway Neurogenesis Neuron Differentiation Cell Proliferation In Midbrain Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Animal Organ Development System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neurogenesis Atrial Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Midbrain Dopaminergic Neuron Differentiation	Water Transport Carbon Dioxide Transport Pancreatic Juice Secretion Odontogenesis Saliva Secretion Camera-type Eye Morphogenesis Protein Homotetramerization Transmembrane Transport Cellular Hypotonic Response
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Passive transport by Aquaporins
GWAS		Dupuytren's disease ( 21732829 28886342 ) Inflammatory bowel disease ( 28067908 ) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573 ) Tonsillectomy ( 27182965 28928442 ) Ulcerative colitis ( 28067908 ) Uterine fibroids ( 31649266 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Allergic rhinitis ( 30013184 ) Asthma ( 32296059 )
Interacting Genes		8 interacting genes: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	8 interacting genes: CREB3 GLRX HNRNPK KRT31 KRT40 MDFI NOTCH2NLA WNT2
Entrez ID		7472	362
HPRD ID		00999	02706
Ensembl ID		ENSG00000105989	ENSG00000161798
Uniprot IDs		A0A384MDX3 P09544	P55064
PDB IDs		Not available	3D9S 5C5X 5DYE 7STC
GO Terms Enriched among Interactors		Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway Wnt-protein Binding Dopaminergic Neuron Differentiation Frizzled Binding Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Presynapse Assembly Wnt Receptor Activity Positive Regulation Of Wnt Signaling Pathway Presynapse Organization Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Cell Surface Regulation Of Cell Junction Assembly Somitogenesis Segmentation Positive Regulation Of Neural Precursor Cell Proliferation Mesoderm Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of BMP Signaling Pathway Convergent Extension Involved In Somitogenesis Neuron Differentiation Negative Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Positive Regulation Of Mesodermal Cell Fate Specification Regulation Of Animal Organ Morphogenesis Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Tissue Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Receptor Clustering Neural Precursor Cell Proliferation Axis Elongation Involved In Somitogenesis Positive Regulation Of Cell Fate Specification Regulation Of Postsynapse To Nucleus Signaling Pathway Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Collateral Sprouting In Absence Of Injury Cellular Response To Lipid Positive Regulation Of Cellular Component Organization Regulation Of BMP Signaling Pathway	Structural Molecule Activity Glutathione Disulfide Oxidoreductase Activity Structural Constituent Of Skin Epidermis Tissue Morphogenesis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Positive Regulation Of Deacetylase Activity Structural Constituent Of Cytoskeleton