WNT2 and FZD9

Number of citations of the paper that reports this interaction (PMID 12138115)
22

Data Source:
HPRD (in vivo)

		WNT2	FZD9
Gene Name		wingless-type MMTV integration site family member 2	frizzled class receptor 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Plasma Membrane Extracellular Matrix	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Agonist Activity	G-protein Coupled Receptor Activity Wnt-protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Cell-cell Signaling Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Neuron Differentiation Lung Development Cell Fate Commitment Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Lung Induction Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Labyrinthine Layer Blood Vessel Development Iris Morphogenesis Mammary Gland Epithelium Development Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway	G-protein Coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Learning Or Memory B Cell Differentiation Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer Metabolic disorders of biological oxidation enzymes GPCR ligand binding WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Dupuytren's disease ( 21732829) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Protein-Protein Interactions		8 interactors: AQP5 FZD1 FZD9 HCK RRAGC SFRP1 UQCR11 WNT3A	6 interactors: KRTAP10-3 MDFI SIAH1 WNT1 WNT2 WNT7A
Entrez ID		7472	8326
HPRD ID		00999	03460
Ensembl ID		ENSG00000105989	ENSG00000188763
Uniprot IDs		A4D0V1 P09544	O00144
PDB IDs
Enriched GO Terms of Interacting Partners?		Canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Wnt Signaling Pathway Regulation Of Embryonic Development Positive Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Osteoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Acid Chemical Regulation Of Catenin Import Into Nucleus Regulation Of Organ Morphogenesis Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Axis Elongation Ossification Negative Regulation Of BMP Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuroblast Proliferation Organ Morphogenesis Cellular Response To Lipid Regulation Of BMP Signaling Pathway Somitogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Respiratory Burst After Phagocytosis Convergent Extension Involved In Somitogenesis Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Positive Regulation Of Mesodermal Cell Fate Specification Stromal-epithelial Cell Signaling Involved In Prostate Gland Development Stem Cell Proliferation Negative Regulation Of Developmental Growth Cellular Response To Organonitrogen Compound Regulation Of Cell Morphogenesis Growth Somite Development Positive Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Neural Precursor Cell Proliferation Negative Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Regulation Of Cardiac Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment	Positive Regulation Of Receptor Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Axis Specification Regulation Of Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Anatomical Structure Morphogenesis Wnt Signaling Pathway Organ Morphogenesis Positive Regulation Of Embryonic Development Cell Fate Commitment Regulation Of Signal Transduction Neuron Differentiation Embryo Development Single Organism Reproductive Process Regulation Of Signaling Cerebellum Morphogenesis Developmental Induction Reproductive Process Embryonic Axis Specification Hindbrain Morphogenesis Cell Differentiation Positive Regulation Of Fibroblast Proliferation Pattern Specification Process Embryonic Organ Development Reproductive Structure Development Generation Of Neurons Reproductive System Development Neurogenesis Skeletal System Development Embryonic Pattern Specification Sensory Organ Development Lens Development In Camera-type Eye Regulation Of Fibroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter System Development Embryonic Morphogenesis Tissue Morphogenesis Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Wnt Signaling Pathway Involved In Wound Healing, Spreading Of Epidermal Cells Embryonic Placenta Development Cerebellum Development Regulation Of Embryonic Development Dorsal/ventral Pattern Formation Positive Regulation Of JNK Cascade Tube Development
Tagcloud ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?		abcb1b administrated brosis colla1 corroborated dkk1 dkk2 dkk3 dkk4 fi frizzled frzb fz1 fz5 fz7 nano nephrotoxicity osteopontin sfrp tio2 wnt1 wnt10a wnt11 wnt3 wnt4 wnt5a wnt6 wnt7a wnt9a	ascl2 c4b dab2ip dlk1 eya4 fabp3 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?