EOMES and PFDN1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		EOMES	PFDN1
Name		eomesodermin	prefoldin subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Endodermal Cell Fate Specification Neuron Migration Blastocyst Development Trophectodermal Cell Differentiation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Brain Development Endoderm Development Anatomical Structure Morphogenesis Cardioblast Differentiation Gene Expression Regulation Of Gene Expression Stem Cell Population Maintenance Olfactory Bulb Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Astrocyte Differentiation Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of definitive endoderm Formation of definitive endoderm Specification of primordial germ cells	Prefoldin mediated transfer of substrate to CCT/TriC
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)	None
GWAS		Ankylosing spondylitis ( 23749187 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Chronic lymphocytic leukemia ( 28165464 26956414 ) Diastolic blood pressure ( 27841878 ) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262 ) Hodgkin's lymphoma ( 24149102 ) Lymphocyte count ( 32888494 ) Macular telangiectasia type 2 ( 33654266 ) Macular thickness ( 30535121 ) Mean arterial pressure ( 29403010 ) Multiple sclerosis ( 24076602 31604244 22190364 21833088 ) PR interval ( 30046033 ) Pulse pressure ( 29403010 ) Rheumatoid arthritis ( 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Systemic lupus erythematosus ( 27399966 ) Systolic blood pressure ( 29403010 ) White blood cell count ( 32888494 )	Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Reaction time ( 29844566 )
Interacting Genes		2 interacting genes: OTP PFDN1	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		8320	5201
HPRD ID		07054	05357
Ensembl ID		ENSG00000163508	ENSG00000113068
Uniprot IDs		B7Z4K0 O95936	O60925
PDB IDs		Not available	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
GO Terms Enriched among Interactors		Neurohypophysis Development Prefoldin Complex Hypothalamus Cell Differentiation Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Neuroendocrine Cell Differentiation Forebrain Neuron Differentiation Neuroepithelial Cell Differentiation Positive Regulation Of Neuroblast Proliferation Dopaminergic Neuron Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Protein Folding Chaperone	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization