EOMES and OTP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EOMES	OTP
Description		eomesodermin	orthopedia homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Endodermal Cell Fate Specification Neuron Migration Blastocyst Development Trophectodermal Cell Differentiation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Brain Development Endoderm Development Anatomical Structure Morphogenesis Cardioblast Differentiation Gene Expression Regulation Of Gene Expression Stem Cell Population Maintenance Olfactory Bulb Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Astrocyte Differentiation Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of DNA-templated Transcription Nervous System Development Neuroblast Proliferation Forebrain Neuron Differentiation Hypothalamus Cell Differentiation Neurohypophysis Development Cell Differentiation Neuron Differentiation Neuroendocrine Cell Differentiation Dopaminergic Neuron Differentiation
Pathways		Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of definitive endoderm Formation of definitive endoderm Specification of primordial germ cells
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Lymphocyte count ( 32888494) Macular telangiectasia type 2 ( 33654266) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Multiple sclerosis ( 24076602 31604244 22190364 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010) White blood cell count ( 32888494)	Age at first sexual intercourse ( 34211149)
Interacting Genes		2 interacting genes: OTP PFDN1	8 interacting genes: BEX1 CCL21 CDK6 CPNE7 EOMES PDE6D SLC12A7 TPGS2
Entrez ID		8320	23440
HPRD ID		07054	05166
Ensembl ID		ENSG00000163508	ENSG00000171540
Uniprot IDs		B7Z4K0 O95936	Q5XKR4
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurohypophysis Development Prefoldin Complex Hypothalamus Cell Differentiation Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Neuroendocrine Cell Differentiation Forebrain Neuron Differentiation Neuroepithelial Cell Differentiation Positive Regulation Of Neuroblast Proliferation Dopaminergic Neuron Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Protein Folding Chaperone	Positive Regulation Of Cell-matrix Adhesion Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Dendritic Cell Dendrite Assembly Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Mesangial Cell-matrix Adhesion CCR7 Chemokine Receptor Binding CCL21-activated CCR7 Signaling Pathway Negative Regulation Of Dendritic Cell Dendrite Assembly CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Regulation Of Cell-matrix Adhesion Stem Cell Differentiation Neurogenesis Positive Regulation Of Cell-substrate Adhesion Regulation Of Dendritic Cell Dendrite Assembly Mesodermal To Mesenchymal Transition Involved In Gastrulation
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