EOMES

Name	eomesodermin
Structure	No pdb structure
Interactors	2 interactors: OTP PFDN1
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Endodermal Cell Fate Specification Neuron Migration Blastocyst Development Trophectodermal Cell Differentiation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Brain Development Endoderm Development Anatomical Structure Morphogenesis Cardioblast Differentiation Gene Expression Regulation Of Gene Expression Stem Cell Population Maintenance Olfactory Bulb Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Neurogenesis Cell Differentiation Neuron Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Astrocyte Differentiation Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation
Pathways	Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of definitive endoderm Formation of definitive endoderm Specification of primordial germ cells
Diseases	Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS	Ankylosing spondylitis ( 23749187 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Chronic lymphocytic leukemia ( 28165464 26956414 ) Diastolic blood pressure ( 27841878 ) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262 ) Hodgkin's lymphoma ( 24149102 ) Lymphocyte count ( 32888494 ) Macular telangiectasia type 2 ( 33654266 ) Macular thickness ( 30535121 ) Mean arterial pressure ( 29403010 ) Multiple sclerosis ( 24076602 31604244 22190364 21833088 ) PR interval ( 30046033 ) Pulse pressure ( 29403010 ) Rheumatoid arthritis ( 24390342 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 ) Systemic lupus erythematosus ( 27399966 ) Systolic blood pressure ( 29403010 ) White blood cell count ( 32888494 )
Entrez ID	8320
HPRD ID	07054
Ensembl ID	ENSG00000163508
Uniprot IDs	B7Z4K0 O95936
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Neurohypophysis Development Prefoldin Complex Hypothalamus Cell Differentiation Negative Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Neuroendocrine Cell Differentiation Forebrain Neuron Differentiation Neuroepithelial Cell Differentiation Positive Regulation Of Neuroblast Proliferation Dopaminergic Neuron Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Protein Folding Chaperone