KCNK12

Description		potassium two pore domain channel subfamily K member 12
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Vitiligo ( 19890347)
Interacting Genes		1 interacting genes: AXIN2
Entrez ID		56660
HPRD ID		09562
Ensembl ID		ENSG00000184261
Uniprot IDs		Q9HB15
PDB IDs
Enriched GO Terms of Interacting Partners?		Intramembranous Ossification Dorsal/ventral Axis Specification Negative Regulation Of Osteoblast Proliferation Maintenance Of DNA Repeat Elements Beta-catenin Destruction Complex Regulation Of Mismatch Repair Osteoblast Proliferation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Centromeric Sister Chromatid Cohesion Heart Field Specification Regulation Of Chondrocyte Development Mitral Valve Morphogenesis Secondary Heart Field Specification Specification Of Animal Organ Identity I-SMAD Binding Regulation Of Sister Chromatid Cohesion Atrioventricular Valve Morphogenesis Cellular Response To Dexamethasone Stimulus Regulation Of Osteoblast Proliferation Aortic Valve Morphogenesis Negative Regulation Of Osteoblast Differentiation Somitogenesis Regulation Of Extracellular Matrix Organization Chondrocyte Differentiation Positive Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus MRNA Stabilization Bone Mineralization Segmentation Cellular Response To Corticosteroid Stimulus Regulation Of Chondrocyte Differentiation Response To Dexamethasone Positive Regulation Of Epithelial To Mesenchymal Transition Heart Valve Morphogenesis Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Steroid Hormone Stimulus RNA Stabilization Stem Cell Proliferation Regulation Of Cartilage Development Axis Specification Beta-catenin Binding Negative Regulation Of RNA Catabolic Process Canonical Wnt Signaling Pathway Odontogenesis Negative Regulation Of MRNA Metabolic Process Biomineral Tissue Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Proteasomal Protein Catabolic Process
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